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Article

Dual direction CRISPR transcriptional regulation screening uncovers gene networks driving drug resistance

Pooled CRISPR–Cas9 knock out screens provide a valuable addition to the methods available for novel drug target identification and validation. However, where gene editing is targeted to amplified loci, the res...

Carlos le Sage, Steffen Lawo, Prince Panicker, Tim M. E. Scales… in Scientific Reports (2017)