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Article
Open AccessPKCδ regulates the vascular biology in diabetic atherosclerosis
Diabetes mellitus, known for its complications, especially vascular complications, is becoming a globally serious social problem. Atherosclerosis has been recognized as a common vascular complication mechanism...
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Article
Open AccessCervical vagal nerve schwannoma induced arrhythmia: a rare case report and literature review
Schwannomas are benign tumors deriving from the sheath of cranial and peripheral nerves. The vagus nerve is comprised of a complex neuro-endocrine-immune network that maintains homeostasis, most tracts of it p...
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Article
Current Status and Prospect of Stent Placement for May-Thurner Syndrome
Stent implantation has been proven to be safe and has become the first-line intervention for May-Thurner syndrome (MTS), with satisfactory mid-term patency rates and clinical outcomes. Recent research has demo...
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Article
Expression Changes of NMDA and AMPA Receptor Subunits in the Hippocampus in rats with Diabetes Induced by Streptozotocin Coupled with Memory Impairment
Cognitive impairment in diabetes (CID) is a severe chronic complication of diabetes mellitus (DM). It has been hypothesized that diabetes can lead to cognitive dysfunction due to expression changes of excitato...
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Article
Structural evolution, electrical properties and electric-field-induced changes of (0.8−x)PbTiO3–xBiFeO3–0.2BaZrO3 system near the morphotropic phase boundary
The crystal structures, piezoelectric property, dielectric transition and electric-field-induced changes in the structures and dielectric constant of (0.8−x)PbTiO3–xBiFeO3–0.2BaZrO3 (0.3 ≤ x ≤ 0.4) ceramics near ...
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Article
Open AccessBrain natriuretic peptide suppresses pain induced by BmK I, a sodium channel-specific modulator, in rats
A previous study found that brain natriuretic peptide (BNP) inhibited inflammatory pain via activating its receptor natriuretic peptide receptor A (NPRA) in nociceptive sensory neurons. A recent study found th...
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Article
Open AccessScorpion toxin BmK I directly activates Nav1.8 in primary sensory neurons to induce neuronal hyperexcitability in rats
Voltage-gated sodium channels (VGSCs) in primary sensory neurons play a key role in transmitting pain signals to the central nervous system. BmK I, a site-3 sodium channel-specific toxin from scorpion Buthus mart...
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Article
Activation of mammalian target of rapamycin contributes to pain nociception induced in rats by BmK I, a sodium channel-specific modulator
The mammalian target of rapamycin (mTOR) pathway is essential for maintenance of the sensitivity of certain adult sensory neurons. Here, we investigated whether the mTOR cascade is involved in scorpion envenom...
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Article
Exploring the obscure profiles of pharmacological binding sites on voltage-gated sodium channels by BmK neurotoxins
Diverse subtypes of voltage-gated sodium channels (VGSCs) have been found throughout tissues of the brain, muscles and the heart. Neurotoxins extracted from the venom of the Asian scorpion Buthus martensi Karsch ...
