25 Result(s)

Article

Selective decontamination of the digestive tract: it’s all in your mind!

Pieter Depuydt, Nicolas Molinari, Romain Sonneville in Intensive Care Medicine (2024)

Article

Selective digestive decontamination - Pro

Jan J. De Waele, Isabel Leroux-Roels, Pieter Depuydt in Intensive Care Medicine (2023)

Article

Pathogen-based target attainment of optimized continuous infusion dosing regimens of piperacillin-tazobactam and meropenem in surgical ICU patients: a prospective single center observational study

Several studies have indicated that commonly used piperacillin-tazobactam (TZP) and meropenem (MEM) dosing regimens lead to suboptimal plasma concentrations for a range of pharmacokinetic/pharmacodynamic (PK/P...

Thomas De Corte, Jarne Verhaeghe, Sofie Dhaese… in Annals of Intensive Care (2023)

Article

Characteristics of Sepsis-2 septic shock patients failing to satisfy the Sepsis-3 septic shock definition: an analysis of real-time collected data

Baseline characteristics and disease severity of patients with septic shock according to the new Sepsis-3 definition may differ from patients that only comply with the Sepsis-2 definition. We conducted a retro...

Joris Vermassen, Johan Decruyenaere, Liesbet De Bus… in Annals of Intensive Care (2021)

Article

Taskforce report on the diagnosis and clinical management of COVID-19 associated pulmonary aspergillosis

Invasive pulmonary aspergillosis (IPA) is increasingly reported in patients with severe coronavirus disease 2019 (COVID-19) admitted to the intensive care unit (ICU). Diagnosis and management of COVID-19 assoc...

Paul E. Verweij, Roger J. M. Brüggemann, Elie Azoulay… in Intensive Care Medicine (2021)

Article

Outcomes of ICU patients with and without perceptions of excessive care: a comparison between cancer and non-cancer patients

Whether Intensive Care Unit (ICU) clinicians display unconscious bias towards cancer patients is unknown. The aim of this study was to compare the outcomes of critically ill patients with and without perceptio...

Dominique D. Benoit, Esther N. van der Zee, Michael Darmon… in Annals of Intensive Care (2021)

Article

Posaconazole for prevention of invasive pulmonary aspergillosis in critically ill influenza patients (POSA-FLU): a randomised, open-label, proof-of-concept trial

Influenza-associated pulmonary aspergillosis (IAPA) is a frequent complication in critically ill influenza patients, associated with significant mortality. We investigated whether antifungal prophylaxis reduce...

Lore Vanderbeke, Nico A. F. Janssen, Dennis C. J. J. Bergmans… in Intensive Care Medicine (2021)

Article

Triage policy of severe Covid-19 patients: what to do now?

Pieter Depuydt, Bertrand Guidet in Annals of Intensive Care (2021)

Article

Review of influenza-associated pulmonary aspergillosis in ICU patients and proposal for a case definition: an expert opinion

Invasive pulmonary aspergillosis is increasingly reported in patients with influenza admitted to the intensive care unit (ICU). Classification of patients with influenza-associated pulmonary aspergillosis (IAP...

Paul E. Verweij, Bart J. A. Rijnders, Roger J. M. Brüggemann… in Intensive Care Medicine (2020)

Article

Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study

The DIANA study aimed to evaluate how often antimicrobial de-escalation (ADE) of empirical treatment is performed in the intensive care unit (ICU) and to estimate the effect of ADE on clinical cure on day 7 fo...

Liesbet De Bus, Pieter Depuydt, Johan Steen, Sofie Dhaese… in Intensive Care Medicine (2020)

Article

Efficacy, immunogenicity, and safety of IC43 recombinant Pseudomonas aeruginosa vaccine in mechanically ventilated intensive care patients—a randomized clinical trial

Pseudomonas aeruginosa infections are a serious threat in intensive care units (ICUs). The aim of this confirmatory, randomized, multicenter, placebo-controlled, double-blind, phase 2/3 study was to assess the ef...

Christopher Adlbrecht, Raphael Wurm, Pieter Depuydt, Herbert Spapen… in Critical Care (2020)

Article

Influence of neutropenia on mortality of critically ill cancer patients: results of a meta-analysis on individual data

The study objective was to assess the influence of neutropenia on outcome of critically ill cancer patients by meta-analysis of individual data. Secondary objectives were to assess the influence of neutropenia...

Quentin Georges, Elie Azoulay, Djamel Mokart, Marcio Soares… in Critical Care (2018)

Article

Beat around the bush for VA-LRTI

Ignacio Martin-Loeches, Pieter Depuydt, Michael S. Niederman in Intensive Care Medicine (2018)

Article

A complete and multifaceted overview of antibiotic use and infection diagnosis in the intensive care unit: results from a prospective four-year registration

Preparing an antibiotic stewardship program requires detailed information on overall antibiotic use, prescription indication and ecology. However, longitudinal data of this kind are scarce. Computerization of ...

Liesbet De Bus, Bram Gadeyne, Johan Steen, Jerina Boelens, Geert Claeys… in Critical Care (2018)

Article

Low flow extracorporeal CO₂ removal in ARDS patients: a prospective short-term crossover pilot study

Lung protective mechanical ventilation (MV) is the corner stone of therapy for ARDS. However, its use may be limited by respiratory acidosis.

Harlinde Peperstraete, Sunny Eloot, Pieter Depuydt, Filip De Somer… in BMC Anesthesiology (2017)

Article

The Intensive Care Medicine research agenda on critically ill oncology and hematology patients

Over the coming years, accelerating progress against cancer will be associated with an increased number of patients who require life-sustaining therapies for infectious or toxic chemotherapy-related events. Ma...

Elie Azoulay, Peter Schellongowski, Michael Darmon… in Intensive Care Medicine (2017)

Article

A randomized placebo-controlled phase II study of a Pseudomonas vaccine in ventilated ICU patients

Currently, no vaccine against Pseudomonas is available. IC43 is a new, recombinant, protein (OprF/I)-based vaccine against the opportunistic pathogen, Pseudomonas aeruginosa, a major cause of serious hospital-acq...

Jordi Rello, Claus-Georg Krenn, Gottfried Locker, Ernst Pilger… in Critical Care (2017)

Article

Oral mucosal adverse events with chlorhexidine 2 % mouthwash in ICU

Nienke L. Plantinga, Bastiaan H. J. Wittekamp, Kris Leleu… in Intensive Care Medicine (2016)