-
Article
In vitro propagated dendritic cells from patients with human-papilloma virus-associated preneoplastic lesions of the uterine cervix: use of Flt3 ligand
Dendritic cells (DC) are the most efficient antigen presenting cells. The clinical use of DC as vectors for antitumor and anti-infectious disease immunotherapy has been limited by their low level and accessibi...
-
Article
Plasmatic cystatin C for the estimation of glomerular filtration rate in intensive care units
To compare the sensitivity of cystatin C and creatinine in detecting decreased glomerular filtration rate.
-
Article
Acetylcysteine and enzymatic creatinine: beware of laboratory artefact!
-
Article
Open AccessMDRD or CKD-EPI study equations for estimating prevalence of stage 3 CKD in epidemiological studies: which difference? Is this difference relevant?
Prevalence of stage 3 chronic kidney disease (CKD) is increasing according to the NHANES study. Prevalence has been calculated using the MDRD study equation for estimating glomerular filtration rate (GFR). Rec...
-
Article
Estimating GFR in children
In a new study, Schwartz and colleagues have investigated the best way to estimate glomerular filtration rate (GFR) in children. Having already improved GFR estimation with the use of creatinine-based equation...
-
Article
Open AccessCreatinine-or cystatin C-based equations to estimate glomerular filtration in the general population: impact on the epidemiology of chronic kidney disease
Chronic kidney disease (CKD) is a major issue in public health. Its prevalence has been calculated using estimation of glomerular filtration rate (GFR) by the creatinine-based equations developed in the Modifi...
-
Article
The applicability of eGFR equations to different populations
Various equations have been developed for estimating glomerular filtration rate (GFR), but the issues surrounding GFR estimation are heavily debated. Although many guidelines now recommend the newer MDRD and C...
-
Article
Open AccessDetection of decreased glomerular filtration rate in intensive care units: serum cystatin C versusserum creatinine
Detecting impaired glomerular filtration rate (GFR) is important in intensive care units (ICU) in order to diagnose acute kidney injuries and adjust the dose of renally excreted drugs. Whether serum Cystatin C...
-
Article
Open AccessDephosphorylated-uncarboxylated Matrix Gla protein concentration is predictive of vitamin K status and is correlated with vascular calcification in a cohort of hemodialysis patients
Matrix Gla protein (MGP) is known to act as a potent local inhibitor of vascular calcifications. However, in order to be active, MGP must be phosphorylated and carboxylated, with this last process being depend...
-
Article
Calibration and precision of serum creatinine and plasma cystatin C measurement: impact on the estimation of glomerular filtration rate
Serum creatinine (SCr) is the main variable for estimating glomerular filtration rate (GFR). Due to inter-assay differences, the prevalence of chronic kidney disease (CKD) varies according to the assay used, a...
-
Article
Abnormal glomerular filtration rate in children, adolescents and young adults starts below 75 mL/min/1.73 m2
The chronic kidney disease (CKD) classification system for children is similar to that for adults, with both mainly based on estimated glomerular filtration rate (eGFR) combined with fixed cut-off values. The ...
-
Chapter
Measurement of Circulating 1,25-Dihydroxyvitamin D and Vitamin D–Binding Protein in Chronic Kidney Diseases
After providing a short reminder on the physiopathology of vitamin D, we will discuss the potential interest to analyze the different metabolites of vitamin D. Undoubtly, measuring 25(OH) vitamin D is one of t...
-
Article
Efficiency of delivery observed treatment in hemodialysis patients: the example of the native vitamin D therapy
Adherence to therapy is a relevant challenge in chronic hemodialysis patients. The directly observed therapy (DOT) could be an effective method to increase adherence for specific therapies. We aimed to study t...
-
Article
Open AccessProceedings of Réanimation 2017, the French Intensive Care Society International Congress
-
Article
The global burden of chronic kidney disease: estimates, variability and pitfalls
Chronic kidney disease (CKD) is presently defined by a matrix of biomarkers, specifically, glomerular filtration rate (GFR) <60 ml/min/1.73 m2 and albuminuria ...
-
Article
Discrepancies between the Cockcroft–Gault and Chronic Kidney Disease Epidemiology (CKD-EPI) Equations: Implications for Refining Drug Dosage Adjustment Strategies
The dosages of many medications require adjustment for renal function. There is debate regarding which equation, the Chronic Kidney Disease Epidemiology (CKD-EPI) equation vs. the Cockcroft–Gault (CG) equation...
-
Article
Open AccessVariations of parathyroid hormone and bone biomarkers are concordant only after a long term follow-up in hemodialyzed patients
End-stage renal disease is associated with mineral and bone disorders. Guidelines recommending therapies should be based on serial assessments of biomarkers, and thus on variations (Δ), rather than scattered v...
-
Article
Evaluation of a New Fully Automated Assay for Plasma Intact FGF23
Several FGF23 immunoassays are available. However, they are reserved for research purposes as none have been approved for clinical use. We evaluated the performances of a new automated assay for intact FGF23 o...
-
Article
Validation of standardized creatinine and cystatin C GFR estimating equations in a large multicentre European cohort of children
Most validations of paediatric glomerular filtration rate (GFR) estimating equations using standardized creatinine (CR) and cystatin C (CYS) assays have comprised relatively small cohorts, which makes accuracy...
-
Article
Evaluation of inactive Matrix-Gla-Protein (MGP) as a biomarker for incident and recurrent kidney stones
Matrix-Gla-protein (MGP) is an inhibitor of vascular calcification. Its dephosphorylated and uncarboxylated inactive form, dpucMGP, is a marker of vitamin K status and of cardio-vascular outcomes in chronic ki...
