13 Result(s)
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Phillip D. Stricker
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Article
Open AccessThe impact of telomere length on prostate cancer aggressiveness, genomic instability and health disparities
The telomere repetitive TTAGGG motif at the ends of chromosomes, serves to preserve genomic integrity and chromosomal stability. In turn, genomic instability is a hallmark of cancer—implicating telomere distur...
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Article
Salvage irreversible electroporation for radio-recurrent prostate cancer
Focal ablative therapy has emerged as a treatment option in radio-recurrent prostate cancer to obtain local control of disease and spare patients severe salvage-treatment-related complications. Irreversible el...
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Article
Open AccessThe relationship between biochemical recurrence and number of lymph nodes removed during surgery for localized prostate cancer
To assess whether completeness of pelvic lymph node dissection (PLND) as measured by lymph node yield reduces biochemical recurrence (BCR) in men undergoing radical prostatectomy (RP) for prostate cancer (PCa)...
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Article
Open AccessAfrican-specific molecular taxonomy of prostate cancer
Prostate cancer is characterized by considerable geo-ethnic disparity. African ancestry is a significant risk factor, with mortality rates across sub-Saharan Africa of 2.7-fold higher than global averages1. The c...
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Article
Open AccessGenome-wide interrogation of structural variation reveals novel African-specific prostate cancer oncogenic drivers
African ancestry is a significant risk factor for advanced prostate cancer (PCa). Mortality rates in sub-Saharan Africa are 2.5-fold greater than global averages. However, the region has largely been excluded ...
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Article
Open AccessSalvage robot-assisted radical prostatectomy following focal ablation with irreversible electroporation: feasibility, oncological and functional outcomes
To report the feasibility, oncological and functional outcomes of salvage robot-assisted radical prostatectomy (sRARP) for recurrent prostate cancer (PCa) after irreversible electroporation (IRE).
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Article
Focal ablation of apical prostate cancer lesions with irreversible electroporation (IRE)
To assess the safety, oncological and quality-of-life (QoL) outcomes of focal ablation of apical prostate cancer (PCa) lesions with irreversible electroporation (IRE).
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Article
Open Accessp53 nuclear accumulation as an early indicator of lethal prostate cancer
After radical prostatectomy (RP) for prostate cancer (PC), p53 alterations predict biochemical relapse (BCR), however, recent evidence suggests that metastatic relapse (MR) not BCR is a surrogate for PC specif...
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Article
Open AccessPair-matched patient-reported quality of life and early oncological control following focal irreversible electroporation versus robot-assisted radical prostatectomy
The design, conduct and completion of randomized trials for curative prostate cancer (PCa) treatments are challenging. To evaluate the effect of robot-assisted radical prostatectomy (RARP) versus focal irrever...
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Article
Open AccessGuidelines for whole genome bisulphite sequencing of intact and FFPET DNA on the Illumina HiSeq X Ten
Comprehensive genome-wide DNA methylation profiling is critical to gain insights into epigenetic reprogramming during development and disease processes. Among the different genome-wide DNA methylation technolo...
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Article
Open AccessAutoStitcher: An Automated Program for Efficient and Robust Reconstruction of Digitized Whole Histological Sections from Tissue Fragments
In applications involving large tissue specimens that have been sectioned into smaller tissue fragments, manual reconstruction of a “pseudo whole-mount” histological section (PWMHS) can facilitate (a) patholog...
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Article
Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer
We have utilized oligonucleotide microarrays to identify novel genes of potential clinical and biological importance in prostate cancer. RNA from 74 prostate cancers and 164 normal body samples representing 40...
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Article
The Incidence, Aetiology, and Presentation of Peyronie's Disease in Sydney, Australia
This paper reports on the incidence, presentation, and aetiological factors of Peyronie's disease in a sexual centre over an 8 year period. Of approximately 13,000 male patients, 672 (5%) were diagnosed with P...
