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Article
Open AccessThe impact of telomere length on prostate cancer aggressiveness, genomic instability and health disparities
The telomere repetitive TTAGGG motif at the ends of chromosomes, serves to preserve genomic integrity and chromosomal stability. In turn, genomic instability is a hallmark of cancer—implicating telomere distur...
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Article
Open AccessProstate cancer genetic risk and associated aggressive disease in men of African ancestry
African ancestry is a significant risk factor for prostate cancer and advanced disease. Yet, genetic studies have largely been conducted outside the context of Sub-Saharan Africa, identifying 278 common risk v...
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Article
Open AccessLinking African ancestral substructure to prostate cancer health disparities
Prostate cancer (PCa) is a significant health burden in Sub-Saharan Africa, with mortality rates loosely linked to African ancestry. Yet studies aimed at identifying contributing risk factors are lacking withi...
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Article
Open AccessANO7 African-ancestral genomic diversity and advanced prostate cancer
Prostate cancer (PCa) is a significant health burden for African men, with mortality rates more than double global averages. The prostate specific Anoctamin 7 (ANO7) gene linked with poor patient outcomes has rec...
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Article
Open AccessAfrican-specific molecular taxonomy of prostate cancer
Prostate cancer is characterized by considerable geo-ethnic disparity. African ancestry is a significant risk factor, with mortality rates across sub-Saharan Africa of 2.7-fold higher than global averages1. The c...
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Article
Author Correction: Human origins in a southern African palaeo-wetland and first migrations
A Correction to this paper has been published: https://doi.org/10.1038/s41586-020-03156-w.
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Article
Open AccessMethylToSNP: identifying SNPs in Illumina DNA methylation array data
Current array-based methods for the measurement of DNA methylation rely on the process of sodium bisulfite conversion to differentiate between methylated and unmethylated cytosine bases in DNA. In the absence ...
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Article
Human origins in a southern African palaeo-wetland and first migrations
Anatomically modern humans originated in Africa around 200 thousand years ago (ka)1–4. Although some of the oldest skeletal remains suggest an eastern African origin2, southern Africa is home to contemporary popu...
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Article
Open AccessAfrican KhoeSan ancestry linked to high-risk prostate cancer
Genetic diversity is greatest within Africa, in particular the KhoeSan click-speaking peoples of southern Africa. South African populations represent admixture fractions including differing degrees of African,...
