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Open AccessAuthor Correction: The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium
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Open AccessThe HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium
The R2TP chaperone cooperates with HSP90 to integrate newly synthesized proteins into multi-subunit complexes, yet its role in tissue homeostasis is unknown. Here, we generated conditional, inducible knock-out...
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Article
Single-cell map** of the thymic stroma identifies IL-25-producing tuft epithelial cells
T cell development and selection are coordinated in the thymus by a specialized niche of diverse stromal populations1–3. Although much progress has been made over the years in identifying the functions of the dif...
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Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites
Epithelial tuft cells secretion of IL-25 is shown to regulate type 2 epithelial responses to helminth parasite infection via an IL-13/IL-4Rα-dependent feedback loop.
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Article
Random chromosome segregation in mouse intestinal epithelial stem cells
The mammalian intestinal epithelium is endowed with a high cell turnover sustained by a few stem cells located in the bottoms of millions of crypts. Until recently, it was generally assumed that the extreme se...
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Open AccessThe intestinal epithelium tuft cells: specification and function
The intestinal epithelium, composed of at least seven differentiated cell types, represents an extraordinary model to understand the details of multi-lineage differentiation, a question that is highly relevant...
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Hierarchy and plasticity in the crypt: back to the drawing board
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Open AccessIntestinal epithelial stem cells do not protect their genome by asymmetric chromosome segregation
The idea that stem cells of adult tissues with high turnover are protected from DNA replication-induced mutations by maintaining the same 'immortal' template DNA strands together through successive divisions h...
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Article
Wnt signalling induces maturation of Paneth cells in intestinal crypts
Wnt signalling, which is transduced through β-catenin/TCF4, maintains the undifferentiated state of intestinal crypt progenitor cells1,2. Mutational activation of the pathway initiates the adenomacarcinoma sequen...
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Diversification Pattern of the HMG and SOX Family Members During Evolution
From a database containing the published HMG protein sequences, we constructed an alignment of the HMG box functional domain based on sequence identity. Due to the large number of sequences (more than 250) an...
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Article
The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal region
Prader-Willi syndrome (PWS) is a neurogenetic disorder that results from the absence of a normal paternal contribution to the 15q11–13 region1–3. The clinical manifestations of PWS are a transient severe hypot...
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Mutations in the human Sonic Hedgehog gene cause holoprosencephaly
Holoprosencephaly (HPE) is a common developmental defect of the forebrain and frequently the midface in humans, with both genetic and environmental causes. HPE has a prevalence of 1:250 during embryogenesis an...
