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Open AccessDynamic changes in extracellular vesicle-associated miRNAs elicited by ultrasound in inflammatory bowel disease patients
Blood-based biomarkers that reliably indicate disease activity in the intestinal tract are an important unmet need in the management of patients with IBD. Extracellular vesicles (EVs) are cell-derived membrano...
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Article
Open AccessFixNCut: single-cell genomics through reversible tissue fixation and dissociation
The use of single-cell technologies for clinical applications requires disconnecting sampling from downstream processing steps. Early sample preservation can further increase robustness and reproducibility by ...
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Article
Open AccessAlterations in the hepatocyte epigenetic landscape in steatosis
Fatty liver disease or the accumulation of fat in the liver, has been reported to affect the global population. This comes with an increased risk for the development of fibrosis, cirrhosis, and hepatocellular ...
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Article
Open AccessDNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon
Genetic variants in the DNA methyltransferase 3 A (DNMT3A) locus have been associated with inflammatory bowel disease (IBD). DNMT3A is part of the epigenetic machinery physiologically involved in DNA methylati...
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Article
Open AccessCohort profile: the Food Chain Plus (FoCus) cohort
The Food Chain Plus (FoCus) cohort was launched in 2011 for population-based research related to metabolic inflammation. To characterize this novel pathology in a comprehensive manner, data collection included...
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Article
Open AccessLongitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease
Treatment with tumor necrosis factor α (TNFα) antagonists in IBD patients suffers from primary non-response rates of up to 40%. Biomarkers for early prediction of therapy success are missing. We investigated t...
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Article
Open AccessCorrection: Circulating levels of soluble Dipeptidylpeptidase-4 are reduced in human subjects hospitalized for severe COVID-19 infections
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Article
Open AccessMultiscale heterogeneity in gastric adenocarcinoma evolution is an obstacle to precision medicine
Cancer is a somatic evolutionary disease and adenocarcinomas of the stomach and gastroesophageal junction (GC) may serve as a two-dimensional model of cancer expansion, in which tumor subclones are not evenly ...
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Article
Open AccessMutational mechanisms sha** the coding and noncoding genome of germinal center derived B-cell lymphomas
B cells have the unique property to somatically alter their immunoglobulin (IG) genes by V(D)J recombination, somatic hypermutation (SHM) and class-switch recombination (CSR). Aberrant targeting of these mecha...
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Article
Open AccessLasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis
The LIM and SH3 domain protein 1 (Lasp1) was originally cloned from metastatic breast cancer and characterised as an adaptor molecule associated with tumourigenesis and cancer cell invasion. However, the regul...
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Article
Open AccessSwarm Learning for decentralized and confidential clinical machine learning
Fast and reliable detection of patients with severe and heterogeneous illnesses is a major goal of precision medicine1,2. Patients with leukaemia can be identified using machine learning on the basis of their blo...
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Open AccessPublisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine
A Correction to this paper has been published: https://doi.org/10.1038/s41586-021-03287-8.
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Open AccessCirculating levels of soluble Dipeptidylpeptidase-4 are reduced in human subjects hospitalized for severe COVID-19 infections
Dipeptidylpeptidase (DPP)-4 is a key regulator of the incretin system. For several years DPP-4 inhibitors in addition to GLP-1 analogues are of major importance in the clinical management of obesity and type 2...
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Article
LifeTime and improving European healthcare through cell-based interceptive medicine
Here we describe the LifeTime Initiative, which aims to track, understand and target human cells during the onset and progression of complex diseases, and to analyse their response to therapy at single-cell re...
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Article
Open AccessDietary lipids fuel GPX4-restricted enteritis resembling Crohn’s disease
The increased incidence of inflammatory bowel disease (IBD) has become a global phenomenon that could be related to adoption of a Western life-style. Westernization of dietary habits is partly characterized by...
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Article
Open AccessRapid response of stage IV colorectal cancer with APC/TP53/KRAS mutations to FOLFIRI and Bevacizumab combination chemotherapy: a case report of use of liquid biopsy
Liquid biopsies of blood plasma cell free DNA can be used to monitor treatment response and potentially detect mutations that are present in resistant clones in metastatic cancer patients.
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Open AccessDietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology
The interaction between the mammalian host and its resident gut microbiota is known to license adaptive immune responses. Nutritional constituents strongly influence composition and functional properties of th...
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Open AccessComparative analysis of amplicon and metagenomic sequencing methods reveals key features in the evolution of animal metaorganisms
The interplay between hosts and their associated microbiome is now recognized as a fundamental basis of the ecology, evolution, and development of both players. These interdependencies inspired a new view of m...
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Open AccessTemperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways
How multicellular organisms assess and control their size is a fundamental question in biology, yet the molecular and genetic mechanisms that control organ or organism size remain largely unsolved. The freshwa...
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Article
Open AccessaFold – using polynomial uncertainty modelling for differential gene expression estimation from RNA sequencing data
Data normalization and identification of significant differential expression represent crucial steps in RNA-Seq analysis. Many available tools rely on assumptions that are often not met by real data, including...
