11 Result(s)
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Article
Open AccessStructure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors
Aminoacyl-tRNA synthetases (aaRSs) play a central role in the translation of genetic code, serving as attractive drug targets. Within this family, the lysyl-tRNA synthetase (LysRS) constitutes a promising anti...
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Article
Open AccessTyrosine-targeted covalent inhibition of a tRNA synthetase aided by zinc ion
Aminoacyl-tRNA synthetases (AARSs), a family of essential protein synthesis enzymes, are attractive targets for drug development. Although several different types of AARS inhibitors have been identified, AARS ...
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Article
A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy
Microphthalmia transcription factor (MITF) regulates melanocyte development and is the “lineage-specific survival” oncogene of melanoma. MITF is essential for melanoma initiation, progression, and relapse and has...
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Article
Human lysyl-tRNA synthetase evolves a dynamic structure that can be stabilized by forming complex
The evolutionary necessity of aminoacyl-tRNA synthetases being associated into complex is unknown. Human lysyl-tRNA synthetase (LysRS) is one component of the multi-tRNA synthetase complex (MSC), which is not ...
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Article
Hearing impairment-associated KARS mutations lead to defects in aminoacylation of both cytoplasmic and mitochondrial tRNALys
Aminoacyl-tRNA synthetases (aaRSs) are ubiquitously expressed, essential enzymes, synthesizing aminoacyl-tRNAs for protein synthesis. Functional defects of aaRSs frequently cause various human disorders. Human KA...
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Article
Photocatalytic property of TiO2 sensitized by different crystal phase CdS
TiO2 samples sensitized by different crystal phase CdS (CT) are synthesized by hydrothermal process at different reaction temperature. The samples are characterized by X-ray diffraction (XRD), transmission electr...
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Article
Interface enhancement of glass fiber/unsaturated polyester resin composites with nano-silica treated using silane coupling agent
Nano-silica treated with different kinds of coupling agent (KH550, A-143, A-151) was used to modify the surface condition of glass fiber, and then, the modified glass fiber/unsaturated polyester resin (UPR) co...
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Article
Study on antireflection SiO2 coatings fabricated by layer-by-layer deposition
Multifunctional (poly(diallyldimethyl ammonium chloride)/ sodium poly(4-styrene sulfonate)) n ((PDDA/PSS) n ) thin films were fabricated by laye...
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Article
Preparation, structure, and properties of polyurethane foams modified by nanoscale titanium dioxide with three different dimensions
TiO2-based nanosheets (TiNSs), TiO2-based nanotubes (TiNTs) were prepared by hydrothermal processing, and polyurethane foams with TiO2 nanopowders (P25), TiNSs and TiNTs were synthesized by free-rising foaming me...
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Article
Photocatalytic activity of TiO2 sensitized by CdS quantum dots under visible-light irradiation
In this paper, CdS quantum dots sensitized TiO2 composite powders (QD-CdS/TiO2) were synthesized by impregnating TiO2 powder into CdS sol with different concentrations. X-ray diffraction pattern (XRD) shows the c...
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Article
Preparation, structure, and properties of flexible polyurethane foams filled with fumed silica
Flexible polyurethane (PU) foams with different loading mass fraction (0%–2.0%) of fumed silica were synthesized by free-rising foaming method. The addition of 1.4% fumed silica makes the cells diffuse more un...
