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  1. No Access

    Article

    A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy

    Microphthalmia transcription factor (MITF) regulates melanocyte development and is the “lineage-specific survival” oncogene of melanoma. MITF is essential for melanoma initiation, progression, and relapse and has...

    Zaizhou Liu, Kaige Chen, Jun Dai, Peng Xu, Wei Sun, Wanlin Liu… in Cell Research (2023)

  2. No Access

    Article

    Human lysyl-tRNA synthetase evolves a dynamic structure that can be stabilized by forming complex

    The evolutionary necessity of aminoacyl-tRNA synthetases being associated into complex is unknown. Human lysyl-tRNA synthetase (LysRS) is one component of the multi-tRNA synthetase complex (MSC), which is not ...

    Siqi Wu, Li Zheng, Zhoufei Hei, **g-Bo Zhou… in Cellular and Molecular Life Sciences (2022)