15 Result(s)

Article

U3 snoRNA inter-regulates with DDX21 in the perichromosomal region to control mitosis

U3 snoRNA is essential for ribosome biogenesis during interphase. Upon mitotic onset, the nucleolus disassembles and U3 snoRNA relocates to the perichromosomal region (PR) to be considered as a chromosome pass...

Yang Jiang, Shiqi Sun, **aofeng Liu, Kunqi Su, Chunfeng Zhang… in Cell Death & Disease (2024)

Article

Genome-wide identification and analysis of the GGCT gene family in wheat

γ-glutamylcyclotransferase (GGCT), an enzyme to maintain glutathione homeostasis, plays a vital role in the response to plant growth and development as well as the adaptation to various stresses. Although the GGC...

Long Zhang, Wanting Sun, Weidong Gao, Yanyan Zhang, Peipei Zhang, Yuan Liu… in BMC Genomics (2024)

Article

Author Correction: Quartet RNA reference materials improve the quality of transcriptomic data through ratio-based profiling

Ying Yu, Wanwan Hou, Yaqing Liu, Haiyan Wang, Lianhua Dong… in Nature Biotechnology (2023)

Article

Quartet RNA reference materials improve the quality of transcriptomic data through ratio-based profiling

Certified RNA reference materials are indispensable for assessing the reliability of RNA sequencing to detect intrinsically small biological differences in clinical settings, such as molecular subty** of dis...

Ying Yu, Wanwan Hou, Yaqing Liu, Haiyan Wang, Lianhua Dong… in Nature Biotechnology (2023)

Article

Multi-omics data integration using ratio-based quantitative profiling with Quartet reference materials

Characterization and integration of the genome, epigenome, transcriptome, proteome and metabolome of different datasets is difficult owing to a lack of ground truth. Here we develop and characterize suites of ...

Yuanting Zheng, Yaqing Liu, **gcheng Yang, Lianhua Dong, Rui Zhang… in Nature Biotechnology (2023)

Article

Bifunctional protein ArsR^M contributes to arsenite methylation and resistance in Brevundimonas sp. M20

Arsenic (As) with various chemical forms, including inorganic arsenic and organic arsenic, is the most prevalent water and environmental toxin. This metalloid occurs worldwide and many of its forms, especially...

Congcong Li, Gongli Zong, ** Chen, Meixia Tan, Wenhui Gao, Jiafang Fu… in BMC Microbiology (2023)

Article

Silencing Notch4 promotes tumorigenesis and inhibits metastasis of triple-negative breast cancer via Nanog and Cdc42

Elucidation of individual Notch protein biology in specific cancer is crucial to develop safe, effective, and tumor-selective Notch-targeting therapeutic reagents for clinical use [1]. Here, we explored the Notch...

Yuan Tian, Peipei Zhang, Yajun Mou, Wenxiu Yang, Junhong Zhang… in Cell Death Discovery (2023)

Article

Deciphering key genomic regions controlling flag leaf size in wheat via integration of meta-QTL and in silico transcriptome assessment

Grain yield is a complex and polygenic trait influenced by the photosynthetic source-sink relationship in wheat. The top three leaves, especially the flag leaf, are considered the major sources of photo-assimi...

Binxue Kong, **gfu Ma, Peipei Zhang, Tao Chen, Yuan Liu, Zhuo Che… in BMC Genomics (2023)

Article

Genes expressed at low levels raise false discovery rates in RNA samples contaminated with genomic DNA

RNA preparations contaminated with genomic DNA (gDNA) are frequently disregarded by RNA-seq studies. Such contamination may generate false results; however, their effect on the outcomes of RNA-seq analyses is ...

**angnan Li, Peipei Zhang, Haijian Wang, Ying Yu in BMC Genomics (2022)

Article

A single-cell transcriptomic landscape of the lungs of patients with COVID-19

The lung is the primary organ targeted by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), making respiratory failure a leading coronavirus disease 2019 (COVID-19)-related mortality. However, our ...

Si Wang, **aohong Yao, Shuai Ma, Yifang **, Yanling Fan… in Nature Cell Biology (2021)

Article

Pyroptosis of syncytia formed by fusion of SARS-CoV-2 spike and ACE2-expressing cells

Huabin Ma, Zhoujie Zhu, Huaipeng Lin, Shanshan Wang, Peipei Zhang… in Cell Discovery (2021)

Article

Integrating longitudinal clinical laboratory tests with targeted proteomic and transcriptomic analyses reveal the landscape of host responses in COVID-19

The pathophysiology of coronavirus disease 19 (COVID-19) involves a multitude of host responses, yet how they unfold during the course of disease progression remains unclear. Here, through integrative analysis...

Yun Tan, Wei Zhang, Zhaoqin Zhu, Niu Qiao, Yun Ling, Mingquan Guo… in Cell Discovery (2021)

Article

Genetic dissection of stem WSC accumulation and remobilization in wheat (Triticum aestivum L.) under terminal drought stress

The accumulation and remobilization of stem water soluble carbohydrates (WSC) are determinant physiological traits highly influencing yield potential in wheat against drought stress. However, knowledge gains o...

Mengfei Li, Yuan Liu, **gfu Ma, Peipei Zhang, Caixiang Wang, Junji Su… in BMC Genetics (2020)

Article

Comparative transcriptome analysis reveals carbohydrate and lipid metabolism blocks in Brassica napus L. male sterility induced by the chemical hybridization agent monosulfuron ester sodium

Chemical hybridization agents (CHAs) are often used to induce male sterility for the production of hybrid seeds. We previously discovered that monosulfuron ester sodium (MES), an acetolactate synthase (ALS) in...

Zhanjie Li, Yufeng Cheng, Jianmin Cui, Peipei Zhang, Huixian Zhao… in BMC Genomics (2015)