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  1. Article

    Open Access

    Analysis of multiple single nucleotide polymorphisms closely positioned in the ovine PRNPgene using linear fluorescent probes and melting curve analysis

    Resistance and susceptibility to scrapie has been associated with single nucleotide polymorphisms located within codons 136, 154 and 171 of the ovine prion protein gene (PRNP). Dual-labelled HyBeacon probes were ...

    David J French, Dominic Jones, David G McDowell, Jim A Thomson… in BMC Infectious Diseases (2007)

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    Chapter

    Minisatellite and Microsatellite DNA Fingerprinting

    Most DNA-based inventions receive much media attention, but have little to show in the end by way of practical outcome. One major exception is DNAfingerprinting and the subsequent variations in mini/microsatel...

    Paul G. Debenham in Molecular Genetic Epidemiology — A Laboratory Perspective (2002)

  3. No Access

    Article

    Heteroplasmy and the Tsar

    Paul G. Debenham in Nature (1996)

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    Article

    Genetics leaves no bones unturned

    Paul G. Debenham in Nature Genetics (1994)

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    Article

    The cloning of the rorB gene of Escherichia coli

    A segment of the Escherichia coli genome which complements the ionising radiation sensitivity of the rorB mutation was cloned into pBR322. This DNA segment also complements the mitomycin C sensitivity of the rorB

    Paul G. Debenham, Michael B. T. Webb, John Law in Molecular and General Genetics MGG (1988)

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    Article

    The isolation and preliminary characterisation of a novel Escherichia coli mutant rorB with enhanced sensitivity to ionising radiation

    Escherichia coli K803 cells were mutagenized and screened for the presence of clones sensitive to ψ-rays but not to ultraviolet light. One new mutant of this type, named rorB, was isolated. This mutant is both c...

    Paul G. Debenham, Michael B. T. Webb in Molecular and General Genetics MGG (1988)

  7. No Access

    Article

    Fingerprinting cell lines: Use of human hypervariable DNA probes to characterize mammalian cell cultures

    Hypervariable DNA sequences may be used as probes to derive DNA “fingerprints” for individuals. To assess the use of the human 33.15 and 33.6 probes (isolated by Jeffreys and coworkers) for characterizing cell.....

    John Thacker, Michael B. T. Webb, Paul G. Debenham in Somatic Cell and Molecular Genetics (1988)

  8. No Access

    Article

    Dominant mutation in mouse cells associated with resistance to Hoechst 33258 dye, but sensitivity to ultraviolet light and DNA base-damaging compounds

    A spontaneous derivative of murine Ltk − cells has been isolated which has gained a resistance to the cytostatic/lethal effects of high concentrations of Hoechst 33258. The resistant clone...

    Paul G. Debenham, Michael B. T. Webb in Somatic Cell and Molecular Genetics (1987)