20 Result(s)

Article

Correction to: Advances and challenges in measuring hepatic glucose uptake with FDG PET: implications for diabetes research

Jeremy Basset‑Sagarminaga, Tineke van de Weijer, Patricia Iozzo… in Diabetologia (2024)

Article

Advances and challenges in measuring hepatic glucose uptake with FDG PET: implications for diabetes research

The liver plays a crucial role in the control of glucose homeostasis and is therefore of great interest in the investigation of the development of type 2 diabetes. Hepatic glucose uptake (HGU) can be measured ...

Jeremy Basset-Sagarminaga, Tineke van de Weijer, Patricia Iozzo… in Diabetologia (2024)

Article

The changing landscape of scientific communication at EASD

Chantal Mathieu, Eleanor Kennedy, Patrick Schrauwen, Hindrik Mulder in Diabetologia (2023)

Article

Timing of physical activity in relation to liver fat content and insulin resistance

We hypothesised that the insulin-sensitising effect of physical activity depends on the timing of the activity. Here, we examined cross-sectional associations of breaks in sedentary time and timing of physical...

Jeroen H. P. M. van der Velde, Sebastiaan C. Boone… in Diabetologia (2023)

Article

Three weeks of time-restricted eating improves glucose homeostasis in adults with type 2 diabetes but does not improve insulin sensitivity: a randomised crossover trial

Time-restricted eating (TRE) is suggested to improve metabolic health by limiting food intake to a defined time window, thereby prolonging the overnight fast. This prolonged fast is expected to lead to a more ...

Charlotte Andriessen, Ciarán E. Fealy, Anna Veelen, Sten M. M. van Beek… in Diabetologia (2022)

Article

The influence of bright and dim light on substrate metabolism, energy expenditure and thermoregulation in insulin-resistant individuals depends on time of day

In our modern society, artificial light is available around the clock and most people expose themselves to electrical light and light-emissive screens during the dark period of the natural light/dark cycle. Su...

Jan-Frieder Harmsen, Jakob Wefers, Daniel Doligkeit, Luc Schlangen… in Diabetologia (2022)

Article

Sitting less elicits metabolic responses similar to exercise and enhances insulin sensitivity in postmenopausal women

In our current society sedentary behaviour predominates in most people and is associated with the risk of develo** type 2 diabetes. It has been suggested that replacing sitting time by standing and walking c...

Carlijn M. E. Remie, Georges E. Janssens, Lena Bilet, Michel van Weeghel… in Diabetologia (2021)

Article

Human skeletal muscle mitochondrial dynamics in relation to oxidative capacity and insulin sensitivity

Mitochondria operate in networks, adapting to external stresses and changes in cellular metabolic demand and are subject to various quality control mechanisms. On the basis of these traits, we here hypothesise...

Alexandre Houzelle, Johanna A. Jörgensen, Gert Schaart, Sabine Daemen… in Diabetologia (2021)

Article

Exercising your fat (metabolism) into shape: a muscle-centred view

Fatty acids are an important energy source during exercise. Training status and substrate availability are determinants of the relative and absolute contribution of fatty acids and glucose to total energy expe...

Anne Gemmink, Patrick Schrauwen, Matthijs K. C. Hesselink in Diabetologia (2020)

Article

One-leg inactivity induces a reduction in mitochondrial oxidative capacity, intramyocellular lipid accumulation and reduced insulin signalling upon lipid infusion: a human study with unilateral limb suspension

Physical inactivity, low mitochondrial function, increased intramyocellular lipid (IMCL) deposition and reduced insulin sensitivity are common denominators of chronic metabolic disorders, like obesity and type...

Lena Bilet, Esther Phielix, Tineke van de Weijer, Anne Gemmink… in Diabetologia (2020)

Article

Underpowered or negative? A crucial distinction. Reply to Dollerup OL, Treebak JT, Jessen N [letter]

Niels J. Connell, Riekelt H. Houtkooper, Patrick Schrauwen in Diabetologia (2019)

Article

NAD⁺ metabolism as a target for metabolic health: have we found the silver bullet?

NAD⁺ has gone in and out of fashion within the scientific community a number of times since its discovery in the early 1900s. Over the last decade, NAD⁺ has emerged as a potential target for combatting metabolic ...

Niels J. Connell, Riekelt H. Houtkooper, Patrick Schrauwen in Diabetologia (2019)

Article

Combatting type 2 diabetes by turning up the heat

In our westernised society, the level of physical activity is low. Interventions that increase energy expenditure are generally associated with an improvement in metabolic health. Exercise and exercise trainin...

Patrick Schrauwen, Wouter D. van Marken Lichtenbelt in Diabetologia (2016)

Article

Effects of exercise training on intrahepatic lipid content in humans

Non-alcoholic fatty liver (NAFL) is the most common liver disorder in western society. Various factors may play a role in determining hepatic fat content, such as delivery of lipids to the liver, de novo lipog...

Bram Brouwers, Matthijs K. C. Hesselink, Patrick Schrauwen… in Diabetologia (2016)

Article

Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans

In contrast to insulin-resistant individuals, insulin-sensitive athletes possess high intramyocellular lipid content (IMCL), good mitochondrial function and high perilipin 5 (PLIN5) levels, suggesting a role f...

Anne Gemmink, Madeleen Bosma, Helma J. H. Kuijpers, Joris Hoeks… in Diabetologia (2016)

Article

ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity

Dissipating energy via mitochondrial uncoupling has been suggested to contribute to enhanced insulin sensitivity. We hypothesised that skeletal muscle mitochondria of endurance-trained athletes have increased ...

Lauren M. Sparks, Anne Gemmink, Esther Phielix, Madeleen Bosma… in Diabetologia (2016)

Article

Cold acclimation and health: effect on brown fat, energetics, and insulin sensitivity

Wouter D van Marken Lichtenbelt, Mark JW Hanssen… in Extreme Physiology & Medicine (2015)

Article

The future of brown adipose tissues in the treatment of type 2 diabetes

The recent recognition that humans possess active depots of brown adipose tissue has boosted the interest in this tissue as a potential target for the prevention and treatment of obesity and related metabolic ...

Patrick Schrauwen, Wouter D. van Marken Lichtenbelt, Bruce M. Spiegelman in Diabetologia (2015)

Article

Glucose uptake in human brown adipose tissue is impaired upon fasting-induced insulin resistance

Human brown adipose tissue (BAT) has recently emerged as a potential target in the treatment of type 2 diabetes, owing to its capacity to actively clear glucose from the circulation—at least upon cold exposure...

Mark J. W. Hanssen, Roel Wierts, Joris Hoeks, Anne Gemmink, Boudewijn Brans… in Diabetologia (2015)