65 Result(s)

Article

Correction to: Advances and challenges in measuring hepatic glucose uptake with FDG PET: implications for diabetes research

Jeremy Basset‑Sagarminaga, Tineke van de Weijer, Patricia Iozzo… in Diabetologia (2024)

Article

Advances and challenges in measuring hepatic glucose uptake with FDG PET: implications for diabetes research

The liver plays a crucial role in the control of glucose homeostasis and is therefore of great interest in the investigation of the development of type 2 diabetes. Hepatic glucose uptake (HGU) can be measured ...

Jeremy Basset-Sagarminaga, Tineke van de Weijer, Patricia Iozzo… in Diabetologia (2024)

Article

A metabolomic signature of decelerated physiological aging in human plasma

The degenerative processes that occur during aging increase the risk of disease and impaired health. Meanwhile, interventions that target aging to promote healthy longevity are gaining interest, both academic...

Georges E. Janssens, Lotte Grevendonk, Bauke V. Schomakers… in GeroScience (2023)

Article

Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes

Cotadutide is a dual glucagon-like peptide 1 and glucagon receptor agonist under development for the treatment of non-alcoholic steatohepatitis and type 2 diabetes mellitus (T2DM) and chronic kidney disease. N...

Victoria E. R. Parker, Darren Robertson, Edmundo Erazo-Tapia… in Nature Metabolism (2023)

Article

PCr/ATP ratios and mitochondrial function in the heart. A comparative study in humans

Cardiac energy status, measured as phosphocreatine (PCr)/adenosine triphosphate (ATP) ratio with 31P-Magnetic Resonance Spectroscopy (31P-MRS) in vivo, is a prognostic factor in heart failure and is lowered in...

Vera H. W. de Wit-Verheggen, Vera B. Schrauwen-Hinderling… in Scientific Reports (2023)

Article

The changing landscape of scientific communication at EASD

Chantal Mathieu, Eleanor Kennedy, Patrick Schrauwen, Hindrik Mulder in Diabetologia (2023)

Article

Timing of physical activity in relation to liver fat content and insulin resistance

We hypothesised that the insulin-sensitising effect of physical activity depends on the timing of the activity. Here, we examined cross-sectional associations of breaks in sedentary time and timing of physical...

Jeroen H. P. M. van der Velde, Sebastiaan C. Boone… in Diabetologia (2023)

Article

Effect of β2-agonist treatment on insulin-stimulated peripheral glucose disposal in healthy men in a randomised placebo-controlled trial

β₂-agonist treatment improves skeletal muscle glucose uptake and whole-body glucose homeostasis in rodents, likely via mTORC2-mediated signalling. However, human data on this topic is virtually absent. We here i....

Sten M. M. van Beek, Yvonne M. H. Bruls, Froukje Vanweert… in Nature Communications (2023)

Article

Three weeks of time-restricted eating improves glucose homeostasis in adults with type 2 diabetes but does not improve insulin sensitivity: a randomised crossover trial

Time-restricted eating (TRE) is suggested to improve metabolic health by limiting food intake to a defined time window, thereby prolonging the overnight fast. This prolonged fast is expected to lead to a more ...

Charlotte Andriessen, Ciarán E. Fealy, Anna Veelen, Sten M. M. van Beek… in Diabetologia (2022)

Article

Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 diabetes

Branched-chain amino acid (BCAA) catabolism has been considered to have an emerging role in the pathogenesis of metabolic disturbances in obesity and type 2 diabetes (T2D). Several studies showed elevated plas...

Froukje Vanweert, Patrick Schrauwen, Esther Phielix in Nutrition & Diabetes (2022)

Article

A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes

Elevations in plasma branched-chain amino acid (BCAA) levels associate with insulin resistance and type 2 diabetes (T2D). Pre-clinical models suggest that lowering BCAA levels improve glucose tolerance, but da...

Froukje Vanweert, Michael Neinast, Edmundo Erazo Tapia… in Nature Communications (2022)

Article

The influence of bright and dim light on substrate metabolism, energy expenditure and thermoregulation in insulin-resistant individuals depends on time of day

In our modern society, artificial light is available around the clock and most people expose themselves to electrical light and light-emissive screens during the dark period of the natural light/dark cycle. Su...

Jan-Frieder Harmsen, Jakob Wefers, Daniel Doligkeit, Luc Schlangen… in Diabetologia (2022)

Article

Genomics and transcriptomics landscapes associated to changes in insulin sensitivity in response to endurance exercise training

Despite good adherence to supervised endurance exercise training (EET), some individuals experience no or little improvement in peripheral insulin sensitivity. The genetic and molecular mechanisms underlying t...

Louise Y. Takeshita, Peter K. Davidsen, John M. Herbert… in Scientific Reports (2021)

Article

Sitting less elicits metabolic responses similar to exercise and enhances insulin sensitivity in postmenopausal women

In our current society sedentary behaviour predominates in most people and is associated with the risk of develo** type 2 diabetes. It has been suggested that replacing sitting time by standing and walking c...

Carlijn M. E. Remie, Georges E. Janssens, Lena Bilet, Michel van Weeghel… in Diabetologia (2021)

Article

The effect of physical activity level and exercise training on the association between plasma branched-chain amino acids and intrahepatic lipid content in participants with obesity

To evaluate whether the association between plasma branched-chain amino acids (BCAA) and intrahepatic lipid (IHL) was affected by physical activity level. Furthermore, to investigate if a conventional exercise...

Froukje Vanweert, Sebastiaan C. Boone, Bram Brouwers… in International Journal of Obesity (2021)

Article

Metabolic responses to mild cold acclimation in type 2 diabetes patients

Mild cold acclimation for 10 days has been previously shown to markedly improve insulin sensitivity in patients with type 2 diabetes. Here we show in a single-arm intervention study (Trialregister.nl ID: NL446...

Carlijn M. E. Remie, Michiel P. B. Moonen, Kay H. M. Roumans… in Nature Communications (2021)