13 Result(s)

Article

Characterisation of FLT3 alterations in childhood acute lymphoblastic leukaemia

Alterations of FLT3 are among the most common driver events in acute leukaemia with important clinical implications, since it allows patient classification into prognostic groups and the possibility of personalis...

Angela Gutierrez-Camino, Chantal Richer, Manon Ouimet… in British Journal of Cancer (2024)

Article

Repurposing disulfiram, an alcohol-abuse drug, in neuroblastoma causes KAT2A downregulation and in vivo activity with a water/oil emulsion

Neuroblastoma, the most common type of pediatric extracranial solid tumor, causes 10% of childhood cancer deaths. Despite intensive multimodal treatment, the outcomes of high-risk neuroblastoma remain poor. We...

Annie Beaudry, Simon Jacques-Ricard, Anaïs Darracq, Nicolas Sgarioto… in Scientific Reports (2023)

Article

Publisher Correction: Single-cell analysis of childhood leukemia reveals a link between developmental states and ribosomal protein expression as a source of intra-individual heterogeneity

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Maxime Caron, Pascal St-Onge, Thomas Sontag, Yu Chang Wang… in Scientific Reports (2021)

Article

An optimized workflow to improve reliability of detection of KIAA1549:BRAF fusions from RNA sequencing data

Alexander C. Sommerkamp, Sebastian Uhrig, Damian Stichel… in Acta Neuropathologica (2020)

Article

Single-cell analysis of childhood leukemia reveals a link between developmental states and ribosomal protein expression as a source of intra-individual heterogeneity

Childhood acute lymphoblastic leukemia (cALL) is the most common pediatric cancer. It is characterized by bone marrow lymphoid precursors that acquire genetic alterations, resulting in disrupted maturation and...

Maxime Caron, Pascal St-Onge, Thomas Sontag, Yu Chang Wang… in Scientific Reports (2020)

Article

Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation

Cardiac glycosides are approved for the treatment of heart failure as Na⁺/K⁺ pump inhibitors. Their repurposing in oncology is currently investigated in preclinical and clinical studies. However, the identificati...

Elodie M. Da Costa, Gregory Armaos… in Journal of Experimental & Clinical Cancer … (2019)

Article

Identification of genetic association between cardiorespiratory fitness and the trainability genes in childhood acute lymphoblastic leukemia survivors

The progress of treatments of childhood acute lymphoblastic leukemia (ALL) has made it possible to reach a survival rate superior to 80%. However, the treatments lead to several long-term adverse effects, incl...

Maxime Caru, Kateryna Petrykey, Simon Drouin, Patrick Beaulieu… in BMC Cancer (2019)

Article

Recurrent somatic BRAF insertion (p.V504_R506dup): a tumor marker and a potential therapeutic target in pilocytic astrocytoma

Pilocytic astrocytoma (PA) is emerging as a tumor entity with dysregulated RAS/RAF/MEK/ERK signaling. In this study, we report the identification of a novel recurrent BRAF insertion (p.V504_R506dup) in five PA...

Fida Khater, Sylvie Langlois, Pauline Cassart, Anne-Marie Roy, Mathieu Lajoie… in Oncogene (2019)

Article

TRPV4 and KRAS and FGFR1 gain-of-function mutations drive giant cell lesions of the jaw

Giant cell lesions of the jaw (GCLJ) are debilitating tumors of unknown origin with limited available therapies. Here, we analyze 58 sporadic samples using next generation or targeted sequencing and report som...

Carolina Cavalieri Gomes, Tenzin Gayden, Andrea Bajic… in Nature Communications (2018)

Article

Genomic determinants of long-term cardiometabolic complications in childhood acute lymphoblastic leukemia survivors

While cure rates for childhood acute lymphoblastic leukemia (cALL) now exceed 80%, over 60% of survivors will face treatment-related long-term sequelae, including cardiometabolic complications such as obesity,...

Jade England, Simon Drouin, Patrick Beaulieu, Pascal St-Onge, Maja Kra**ovic… in BMC Cancer (2017)