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Article
Efficient and irreversible antibody–cysteine bioconjugation using carbonylacrylic reagents
There is considerable interest in the development of chemical methods for the precise, site-selective modification of antibodies for therapeutic applications. In this protocol, we describe a strategy for the i...
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Article
Open AccessA fully human anti-IL-7Rα antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological cancer for which treatment options often result in incomplete therapeutic efficacy and long-term side-effects. Interleukin 7 (IL-7) an...
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Article
Open AccessNRARP displays either pro- or anti-tumoral roles in T-cell acute lymphoblastic leukemia depending on Notch and Wnt signaling
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with a dismal prognosis in patients with resistant or relapsed disease. Although NOTCH is a known driver in T-ALL, its clin...
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Article
Open AccessCD98hc is a target for brain delivery of biotherapeutics
Brain exposure of systemically administered biotherapeutics is highly restricted by the blood-brain barrier (BBB). Here, we report the engineering and characterization of a BBB transport vehicle targeting the ...
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Article
Open AccessAuthor Correction: CD98hc is a target for brain delivery of biotherapeutics
