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Article
Open AccessNecroptosis induced by ruthenium (II) complexes as mitochondrial disruptors
Inducing necroptosis in cancer cells has emerged as an effective strategy to overcome drug resistance. However, while organic small molecules have been extensively studied for this purpose, metal-based compoun...
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Article
Open AccessNeurobehavioral sex-related differences in Nf1+/− mice: female show a “camouflaging”-type behavior
Neurofibromatosis type 1 (NF1) is an inherited neurocutaneous disorder associated with neurodevelopmental disorders including autism spectrum disorder (ASD). This condition has been associated with an increase...
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Living Reference Work Entry In depth
Amphetamine in biological specimens: impact and implications for public health
Amphetamine was synthesized in the mid-nineteenth century, and an enormous number of derivatives have appeared ever since, being the consumption of these compounds a serious public health problem. While they h...
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Reference Work Entry In depth
Amphetamine in Biological Specimens: Impact and Implications for Public Health
Amphetamine was synthesized in the mid-nineteenth century, and an enormous number of derivatives have appeared ever since, being the consumption of these compounds a serious public health problem. While they h...
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Chapter
How Green Is the Green Energy Transition? On the Road to Decarbonization
This chapter provides a detailed analysis of the various forces at work, which have been acting as obstacles to the widespread adoption of so-called alternative energies and the prolonged use of fossil fuels. ...
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Article
Pre-Clinical Assessment of the Nose-to-Brain Delivery of Zonisamide After Intranasal Administration
Zonisamide clinical indications are expanding beyond the classic treatment of epileptic seizures to Parkinson’s disease and other neurodegenerative diseases. However, the systemic safety profile of zonisamide ...
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Article
Determination of N,N-dimethyltryptamine and beta-carbolines in plants used to prepare ayahuasca beverages by means of solid-phase extraction and gas-chromatography–mass spectrometry
The goal of the present work was the development of a method to determine beta-carbolines, i.e., tetrahydroharmine, harmine, and harmaline, together with N,N-dimethyltryptamine present in five different commercia...
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Article
Open AccessNRARP displays either pro- or anti-tumoral roles in T-cell acute lymphoblastic leukemia depending on Notch and Wnt signaling
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with a dismal prognosis in patients with resistant or relapsed disease. Although NOTCH is a known driver in T-ALL, its clin...
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Article
Development and validation of a HPLC–DAD method for quantification of phenolic compounds in different sweet cherry cultivars
This work describes the validation of a new high-performance liquid chromatography method for the determination of nine phenolic compounds in six cultivars of sweet cherries. Phenolic compounds are a wide and ...
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Chapter and Conference Paper
Comparative Analysis of Inspection and Diagnosis Tools for Ancient Buildings
The survey and inspection of the state of conservation of buildings is understood as an active process of selecting information to support decision making in the rehabilitation of the built heritage. The devel...
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Article
Open AccessTesting the excitation/inhibition imbalance hypothesis in a mouse model of the autism spectrum disorder: in vivo neurospectroscopy and molecular evidence for regional phenotypes
Excitation/inhibition (E/I) imbalance remains a widely discussed hypothesis in autism spectrum disorders (ASD). The presence of such an imbalance may potentially define a therapeutic target for the treatment o...
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Article
A multiplex PCR assay for identification of the red fox (Vulpes vulpes) using the mitochondrial ribosomal RNA genes
The European red fox (Vulpes vulpes) is a highly adaptable predator indigenous to the northern hemisphere. However, in Australia the red fox is a widespread exotic predator that has contributed to the decline and...
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Article
Open AccessPrevention of methamphetamine-induced microglial cell death by TNF-α and IL-6 through activation of the JAK-STAT pathway
It is well known that methamphetamine (METH) is neurotoxic and recent studies have suggested the involvement of neuroinflammatory processes in brain dysfunction induced by misuse of this drug. Indeed, glial ce...
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Article
Open AccessHistamine modulates microglia function
Histamine is commonly acknowledged as an inflammatory mediator in peripheral tissues, leaving its role in brain immune responses scarcely studied. Therefore, our aim was to uncover the cellular and molecular m...
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Article
Open AccessProliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations
Thyroid carcinomas show a high prevalence of mutations in the oncogene BRAF which are inversely associated with RAS or RET/PTC oncogenic activation. The possibility of using inhibitors on the BRAF pathway as b...
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Chapter and Conference Paper
Peer-Level Analysis of Distributed Multimedia Content Sharing
In the last few years, peer-to-peer (P2P) file-sharing applications have become very popular: more users are continuously joining such systems and more objects are being made available, seducing even more user...
