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Article
Phenotypic and genotypic characteristics of women in relation to personality traits
The associations were examined in women between personality traits and steroid hormones, particularly androgens, as well as polymorphisms in genes regulating androgen concentration and effects. Women, all 42 y...
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Article
Association between a dinucleotide repeat polymorphism of the estrogen receptor alpha gene and personality traits in women
Estrogens are known to play a key role in the regulation of various aspects of behavior. In order to study the potential contribution of genetic variation in the estrogen receptor (ER) alpha to specific person...
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Article
Allelic variants in the GABAAα6 receptor subunit gene (GABRA6) is associated with abdominal obesity and cortisol secretion
Introduction: Cortisol is involved in the regulation of adipose-tissue differentiation, function and distribution, and in excess causes abdominal obesity. At the level of the brain, cortisol secretion is partly c...
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Article
Central and peripheral glucocorticoid receptor function in abdominal obesity
Abdominal obesity seems to be associated with a moderately deranged feedback regulation of the hypothalamic-pituitary-adrenal (HPA) axis where central glucocorticoid receptors (GR) are involved. Therefore, fun...
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Article
A missense mutation in the human melanocortin-4 receptor gene in relation to abdominal obesity and salivary cortisol
The melanocortin-4 receptor (MC4-R) regulates food intake and possibly energy expenditure, and the inactivation of the MC4-R by gene targeting results in obesity, a phenotype strongly associated with Type II ...
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Article
New targets for the clinical assessment of salivary cortisol secretion
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Article
Polymorphism in exon 6 of the dopamine D2 receptor gene (DRD2) is associated with elevated blood pressure and personality disorders in men
A deficient dopamine D2 receptor (DA2) formation or action may contribute to hypertension via an increase of catecholamine release. In addition, Axis II personality disorders that appears odd or eccentric (cluste...
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Article
Relationships between personality disorders and anthropometry, hormones and metabolism in women
This study sought to examine the potential influence of personality disorders (PD) on anthropometry, hormones and metabolism in women. In a population sample of women born in 1956 (no.=270), estimates of PD:s ...
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Article
Neuroendocrine abnormalities in visceral obesity
Central obesity is the subfraction which carries most of the risks for comorbidities. In this overview we suggest that this is due to neuroendocrine perturbations, where the hypothalamic–pituitary–adrenal (HPA...
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Article
Food-induced cortisol secretion in relation to anthropometric, metabolic and haemodynamic variables in men
OBJECTIVE: To assess the relationships between the regulation of diurnal and food-induced cortisol secretion and anthropometric, metabolic and haemodynamic variables in middle-aged men.
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Chapter
Fat Metabolism in Obesity, with Special Emphasis on the Insulin Resistance and Elevated Lipid Mobilization in Visceral Obesity
Adipose tissue is the main tissue for storage of lipid energy. A normal subject carries about 10-15 kg fat, corresponding to the energy needs of about a month. Obviously this large energy depot transports larg...
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Article
Personality disorders in relation to anthropometric, endocrine and metabolic factors
Subjects with abdominal obesity show several signs of a perturbed regulation of the hypothalamic- pituitary-adrenal (HPA) axis. This is known to occur after chronic, submissive stress. Perceived environmental ...
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Article
Psychosocial and socio-economic factors in women and their relationship to obesity and regional body fat distribution
BACKGROUND: Abdominal obesity, as well as psychosocial and socio-economic handicaps are risk factors for serious, prevalent diseases. Connections between these variables have been found in men.
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Article
The interactions between hypothalamic-pituitary-adrenal axis activity, testosterone, insulin-like growth factor I and abdominal obesity with metabolism and blood pressure in men
OBJECTIVE: To examine potential interactions between abdominal obesity, endocrine, metabolic and hemodynamic perturbations.
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Article
Secular increases in waist–hip ratio among Swedish women
INTRODUCTION: Secular increases in obesity have been documented in numerous populations. However, little is known about trends in fat distribution. Because men and women with elevated waist–hip ratios (WHR) co...
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Article
Urinary albumin excretion and heart rate variability in obese women
OBJECTIVE: The aim of this work was to examine the relationship between cardiac autonomic function and urinary albumin excretion in obesity.
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Article
Comparison of cardiovascular risk profile between male employees of two automotive companies in France and Sweden
To determine whether or not the lower rate of coronary disease in France, in comparison with Sweden, might be explained by different cardiovascular risk profiles, a cross-sectional analysis (first step of a lo...
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Article
Rapid formation of capillary endothelial cells in rat skeletal muscle after exposure to insulin
Research has suggested a role for insulin delivery through capillaries in muscle in the regulation of insulin sensitivity. Therefore, the formation and turn-over of capillary endothelial cells in muscle were s...
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Chapter
Body Fat Distribution and Cardiovascular Disease
The association between obesity and cardiovascular disease (CVD) has been unclear, non-consistent and controversial. Recent developments have, however, apparently clarified these enigmatic conditions by includ...
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Article
Haemodynamic, metabolic and endocrine effects of short-term dexfenfluramine treatment in young, obese women
Seventeen normotensive, premenopausal women were treated with the 5-hydroxytryptamine-reuptake inhibitor dexfenfluramine 30 mg per day, for 4 days in a randomised double-blind, cross-over, placebo controlled t...
