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  1. No Access

    Article

    Cyr61 silencing reduces vascularization and dissemination of osteosarcoma tumors

    Osteosarcoma is the most prevalent primary pediatric cancer-related bone disease. These tumors frequently develop resistance to chemotherapy and are highly metastatic, leading to poor outcome. Thus, there is a...

    N Habel, M Vilalta, O Bawa, P Opolon, J Blanco, O Fromigué in Oncogene (2015)

  2. Article

    Open Access

    Radiosensitization by a novel Bcl-2 and Bcl-XL inhibitor S44563 in small-cell lung cancer

    Radiotherapy has a critical role in the treatment of small-cell lung cancer (SCLC). The effectiveness of radiation in SCLC remains limited as resistance results from defects in apoptosis. In the current study,...

    Y Loriot, P Mordant, D Dugue, O Geneste, A Gombos, P Opolon… in Cell Death & Disease (2014)

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  3. Article

    Open Access

    CXCR4 inhibitors selectively eliminate CXCR4-expressing human acute myeloid leukemia cells in NOG mouse model

    The chemokine receptor CXCR4 favors the interaction of acute myeloid leukemia (AML) cells with their niche but the extent to which it participates in pathogenesis is unclear. Here, we show that CXCR4 expressio...

    Y Zhang, S Patel, H Abdelouahab, M Wittner, C Willekens, S Shen… in Cell Death & Disease (2012)

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  4. No Access

    Article

    Validation of a mutated PRE sequence allowing high and sustained transgene expression while abrogating WHV-X protein synthesis: application to the gene therapy of WAS

    The woodchuck hepatitis virus posttranscriptional regulatory element (WPRE) is widely used in retroviral gene transfer vectors. However, this element contains an open-reading frame (ORF) encoding a truncated p...

    M A Zanta-Boussif, S Charrier, A Brice-Ouzet, S Martin, P Opolon… in Gene Therapy (2009)

  5. No Access

    Article

    Canstatin gene electrotransfer combined with radiotherapy: preclinical trials for cancer treatment

    Given as a prophylactic treatment, a single muscle electrogene transfer of plasmid coding canstatin fused to human serum albumin (CanHSA), slowed down the development of two xenografted human carcinomas from m...

    C Magnon, P Opolon, E Connault, L M Mir, M Perricaudet, D Martel-Renoir in Gene Therapy (2008)

  6. Article

    Erratum: Respective roles of TNF-α and IL-6 in the immune response-elicited by adenovirus-mediated gene transfer in mice

    Correction to: Gene Therapy (2007) 14, 533–544. doi:10.1038/sj.gt.3302885 Since the above publication, the authors have noticed an error in the author affiliations. The correct affiliations are shown above. Th...

    K Benihoud, S Esselin, D Descamps, B Jullienne, B Salone, P Bobé… in Gene Therapy (2007)

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  7. No Access

    Article

    Respective roles of TNF-α and IL-6 in the immune response-elicited by adenovirus-mediated gene transfer in mice

    The immunogenicity of recombinant adenoviruses (Ad) constitutes a major concern for their use in gene therapy. Antibody- and cell-mediated immune responses triggered by adenoviral vectors hamper long-term tran...

    K Benihoud, S Esselin, D Descamps, B Jullienne, B Salone, P Bobé… in Gene Therapy (2007)

  8. Article

    Erratum: Dynamic assessment of antiangiogenic therapy by monitoring both tumoral vascularization and tissue degeneration

    Correction to: Gene Therapy (2007) 14, 108–117. doi:10.1038/sj.gt.3302849 In the original publication, the affiliations linked to N Lassau were published incorrectly. The correct linked affiliations are given ...

    C Magnon, A Galaup, V Rouffiac, P Opolon, E Connault, M Rosé, M Perricaudet… in Gene Therapy (2007)

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  9. No Access

    Article

    Dynamic assessment of antiangiogenic therapy by monitoring both tumoral vascularization and tissue degeneration

    Tumor growth is dependent both on endothelial and tumor cells. The aim of this study was to investigate dynamically whether changes in tumor vasculature implicate tumor tissue degeneration during antiangiogeni...

    C Magnon, A Galaup, V Rouffiac, P Opolon, E Connault, M Rosé, M Perricaudet… in Gene Therapy (2007)

  10. No Access

    Article

    Variability of naked DNA expression after direct local injection: the influence of the injection speed

    The simple injection of DNA into muscles is known to result in the expression of the injected genes, even though at low and variable levels. We report that this variability in DNA expression is partly dependen...

    F M André, C Cournil-Henrionnet, D Vernerey, P Opolon, L M Mir in Gene Therapy (2006)

  11. No Access

    Article

    Pleiotrophin, a candidate gene for poor tumor vasculature and in vivo neuroblastoma sensitivity to irinotecan

    In vivo neuroblastoma (NB) xenograft model, resistant to the DNA-topoisomerase I inhibitor irinotecan (CPT-11), has been established to study resistance mechanisms acquired in a therapeutic setting. Common mechan...

    L Calvet, B Geoerger, M Regairaz, P Opolon, L Machet, J Morizet, J-M Joseph… in Oncogene (2006)

  12. No Access

    Article

    The tumor suppressor activity induced by adenovirus-mediated BRCA1 overexpression is not restricted to breast cancers

    The BRCA1 (breast cancer 1) breast cancer susceptibility gene is recognized as responsible for most familial breast and ovarian cancers and is suggested to be a tissue-specific tumor suppressor gene. In this repo...

    D Marot, P Opolon, S Brailly-Tabard, N Elie, V Randrianarison, E Connault… in Gene Therapy (2006)

  13. No Access

    Article

    Full kringles of plasminogen (aa 1–566) mediate complete regression of human MDA-MB-231 breast tumor xenografted in nude mice

    Since kringle (K)5, not present in the angiostatin molecule, was shown to be a key functional domain possessing potent antiangiogenic activity, we have evaluated a new plasminogen-derived fragment, consisting ...

    A Galaup, C Magnon, V Rouffiac, P Opolon, D Opolon, N Lassau, T Tursz… in Gene Therapy (2005)

  14. No Access

    Article

    A lentiviral vector encoding the human Wiskott–Aldrich syndrome protein corrects immune and cytoskeletal defects in WASP knockout mice

    Wiskott–Aldrich syndrome (WAS) is an immune deficiency with thrombopenia resulting from mutations in the WASP gene. This gene normally encodes the Wiskott–Aldrich syndrome protein (WASP), a major cytoskeletal ...

    S Charrier, D Stockholm, K Seye, P Opolon, M Taveau, D-A Gross… in Gene Therapy (2005)

  15. No Access

    Article

    Fenofibrate inhibits angiogenesis in vitro and in vivo

    Fenofibrate, a peroxisome proliferator-activated receptor (PPAR)-alpha activator, used as a normolipidemic agent, is thought to offer additional beneficial effects in atherosclerosis. Since angiogenesis is in...

    J. Varet, L. Vincent, P. Mirshahi, J.-V. Pille… in Cellular and Molecular Life Sciences CMLS (2003)

  16. No Access

    Article

    Recombinant adenovirus shedding after intratumoral gene transfer in lung cancer patients

    We conducted two phase 1 trials of direct intratumoral injection of a recombinant E1E3-deleted adenovirus (AdR) encoding either the bacterial enzyme β-galactosidase (Ad.RSVβgal) or interleukin 2 (IL2, AdTG5327...

    F Griscelli, P Opolon, P Saulnier, F Mami-Chouaib, E Gautier, H Echchakir… in Gene Therapy (2003)

  17. No Access

    Article

    Adenovirus-mediated gene transfer of urokinase plasminogen inhibitor inhibits angiogenesis in experimental arthritis

    Plasmin is essential for metalloproteases activation, endothelial cell migration and degradation of the extracellular matrix. The process is common to neoangiogenesis pannus formation and cartilage degradation...

    F Apparailly, C Bouquet, V Millet, D Noel, C Jacquet, P Opolon… in Gene Therapy (2002)

  18. No Access

    Article

    Angiogenesis induced in muscle by a recombinant adenovirus expressing functional isoforms of basic fibroblast growth factor

    The present work studies the effects of a replication-deficient adenovirus (Ad), Ad-RSVbFGF, bearing the human basic fibroblast growth factor (bFGF) cDNA, as a potential vector for therapeutic angiogenesis of ...

    C Garcia-Martinez, P Opolon, V Trochon, C Chianale, K Musset, H Lu… in Gene Therapy (1999)

  19. No Access

    Article

    Adenovirus-mediated delivery of a uPA/uPAR antagonist suppresses angiogenesis-dependent tumor growth and dissemination in mice

    AdmATF is a recombinant adenovirus encoding a secreted version of the amino-terminal fragment (ATF) of murine urokinase (uPA). This defective adenovirus was used in three murine models to assess the antitumora...

    H Li, H Lu, F Griscelli, P Opolon, L-Q Sun, T Ragot, Y Legrand, D Belin… in Gene Therapy (1998)