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Article
GRASP with path-relinking for the non-identical parallel machine scheduling problem with minimising total weighted completion times
In this work, we tackle the problem of scheduling a set of jobs on a set of non-identical parallel machines with the goal of minimising the total weighted completion times. GRASP is a multi-start method that c...
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Chapter and Conference Paper
Memetic Algorithm for Intense Local Search Methods Using Local Search Chains
This contribution presents a new memetic algorithm for continuous optimization problems, which is specially designed for applying intense local search methods. These local search methods make use of explicit s...
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Chapter and Conference Paper
An Evolutionary ILS-Perturbation Technique
This contribution proposes a new perturbation technique for the iterated local search metaheuristic, which consists in a micro evolutionary algorithm that effectively explores the neighborhood of the solution ...
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Article
Angiogenesis induced in muscle by a recombinant adenovirus expressing functional isoforms of basic fibroblast growth factor
The present work studies the effects of a replication-deficient adenovirus (Ad), Ad-RSVbFGF, bearing the human basic fibroblast growth factor (bFGF) cDNA, as a potential vector for therapeutic angiogenesis of ...
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Article
Stereocontrolled synthesis of 3-alkylindolines from (Z)-2-hydroxyindolenines
A convenient process for the synthesis of 3-alkylindolines2 and their transformation intocis-fused tricyclic γ-lactones3 from allylic alcohols1, mediated by aGrignard reagent, is described. This process proceeds ...
