32 Result(s)

Article

Cyr61 silencing reduces vascularization and dissemination of osteosarcoma tumors

Osteosarcoma is the most prevalent primary pediatric cancer-related bone disease. These tumors frequently develop resistance to chemotherapy and are highly metastatic, leading to poor outcome. Thus, there is a...

N Habel, M Vilalta, O Bawa, P Opolon, J Blanco, O Fromigué in Oncogene (2015)

Article

Isocitrate dehydrogenase (IDH)2 R140Q mutation induces myeloid and lymphoid neoplasms in mice

E Mylonas, M Janin, O Bawa, P Opolon, M David, C Quivoron, O A Bernard… in Leukemia (2014)

Article

The soluble fragment of VE-cadherin inhibits angiogenesis by reducing endothelial cell proliferation and tube capillary formation

Vascular endothelial-specific cadherin (VE-cadherin) is an endothelial cell-specific adhesion molecule, localized at cell–cell contact sites. It is involved in physiological and pathological angiogenesis. In t...

H Li, X Shi, J Liu, C Hu, X Zhang, H Liu, J **, P Opolon… in Cancer Gene Therapy (2010)

Article

Validation of a mutated PRE sequence allowing high and sustained transgene expression while abrogating WHV-X protein synthesis: application to the gene therapy of WAS

The woodchuck hepatitis virus posttranscriptional regulatory element (WPRE) is widely used in retroviral gene transfer vectors. However, this element contains an open-reading frame (ORF) encoding a truncated p...

M A Zanta-Boussif, S Charrier, A Brice-Ouzet, S Martin, P Opolon… in Gene Therapy (2009)

Article

Canstatin gene electrotransfer combined with radiotherapy: preclinical trials for cancer treatment

Given as a prophylactic treatment, a single muscle electrogene transfer of plasmid coding canstatin fused to human serum albumin (CanHSA), slowed down the development of two xenografted human carcinomas from m...

C Magnon, P Opolon, E Connault, L M Mir, M Perricaudet, D Martel-Renoir in Gene Therapy (2008)

Article

Respective roles of TNF-α and IL-6 in the immune response-elicited by adenovirus-mediated gene transfer in mice

The immunogenicity of recombinant adenoviruses (Ad) constitutes a major concern for their use in gene therapy. Antibody- and cell-mediated immune responses triggered by adenoviral vectors hamper long-term tran...

K Benihoud, S Esselin, D Descamps, B Jullienne, B Salone, P Bobé… in Gene Therapy (2007)

Article

A gene transfer comparative study of HSA-conjugated antiangiogenic factors in a transgenic mouse model of metastatic ocular cancer

Different antiangiogenic and antimetastatic recombinant adenoviruses were tested in a transgenic mouse model of metastatic ocular cancer (TRP1/SV40 Tag transgenic mice), which is a highly aggressive tumor, dev...

E Frau, C Magnon, P Opolon, E Connault, D Opolon, F Beerman… in Cancer Gene Therapy (2007)

Article

Dynamic assessment of antiangiogenic therapy by monitoring both tumoral vascularization and tissue degeneration

Tumor growth is dependent both on endothelial and tumor cells. The aim of this study was to investigate dynamically whether changes in tumor vasculature implicate tumor tissue degeneration during antiangiogeni...

C Magnon, A Galaup, V Rouffiac, P Opolon, E Connault, M Rosé, M Perricaudet… in Gene Therapy (2007)

Article

Variability of naked DNA expression after direct local injection: the influence of the injection speed

The simple injection of DNA into muscles is known to result in the expression of the injected genes, even though at low and variable levels. We report that this variability in DNA expression is partly dependen...

F M André, C Cournil-Henrionnet, D Vernerey, P Opolon, L M Mir in Gene Therapy (2006)

Article

Pleiotrophin, a candidate gene for poor tumor vasculature and in vivo neuroblastoma sensitivity to irinotecan

In vivo neuroblastoma (NB) xenograft model, resistant to the DNA-topoisomerase I inhibitor irinotecan (CPT-11), has been established to study resistance mechanisms acquired in a therapeutic setting. Common mechan...

L Calvet, B Geoerger, M Regairaz, P Opolon, L Machet, J Morizet, J-M Joseph… in Oncogene (2006)

Article

The tumor suppressor activity induced by adenovirus-mediated BRCA1 overexpression is not restricted to breast cancers

The BRCA1 (breast cancer 1) breast cancer susceptibility gene is recognized as responsible for most familial breast and ovarian cancers and is suggested to be a tissue-specific tumor suppressor gene. In this repo...

D Marot, P Opolon, S Brailly-Tabard, N Elie, V Randrianarison, E Connault… in Gene Therapy (2006)

Article

Full kringles of plasminogen (aa 1–566) mediate complete regression of human MDA-MB-231 breast tumor xenografted in nude mice

Since kringle (K)5, not present in the angiostatin molecule, was shown to be a key functional domain possessing potent antiangiogenic activity, we have evaluated a new plasminogen-derived fragment, consisting ...

A Galaup, C Magnon, V Rouffiac, P Opolon, D Opolon, N Lassau, T Tursz… in Gene Therapy (2005)

Article

A lentiviral vector encoding the human Wiskott–Aldrich syndrome protein corrects immune and cytoskeletal defects in WASP knockout mice

Wiskott–Aldrich syndrome (WAS) is an immune deficiency with thrombopenia resulting from mutations in the WASP gene. This gene normally encodes the Wiskott–Aldrich syndrome protein (WASP), a major cytoskeletal ...

S Charrier, D Stockholm, K Seye, P Opolon, M Taveau, D-A Gross… in Gene Therapy (2005)