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Article
Discovery of novel drug sensitivities in T-PLL by high-throughput ex vivo drug testing and mutation profiling
T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive neoplasm of mature T-cells with an urgent need for rationally designed therapies to address its notoriously chemo-refractory behavior. The median...
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Article
Monitoring therapy responses at the leukemic subclone level by ultra-deep amplicon resequencing in acute myeloid leukemia
In our individualized systems medicine program, personalized treatment options are identified and administered to chemorefractory acute myeloid leukemia (AML) patients based on exome sequencing and ex vivo drug s...
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Article
Activating somatic mutations outside the SH2-domain of STAT3 in LGL leukemia