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Article
A Novel Mechanism of Renal Microcirculation Regulation: Connecting Tubule-Glomerular Feedback
In this review, we summarized the current knowledge of connecting tubule-glomerular feedback (CTGF), a novel mechanism of renal microcirculation regulation that integrates sodium handling in the connecting tub...
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Article
N-acetyl-Ser-Asp-Lys-Pro inhibits interleukin-1β-mediated matrix metalloproteinase activation in cardiac fibroblasts
Myocardial matrix turnover involves a dynamic balance between collagen synthesis and degradation, which is regulated by matrix metalloproteinases (MMPs). N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) is a small peptide that...
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Article
N-Acetyl–seryl–aspartyl–lysyl–proline inhibits ET-1-induced collagen production by preserving Src homology 2-containing protein tyrosine phosphatase-2 activity in cardiac fibroblasts
N–Acetyl–seryl–aspartyl–lysyl–proline (Ac-SDKP) inhibits endothelin-1 (ET-1)-induced activation of p44/42 mitogen-activated protein kinase (p44/42 MAPK) and collagen production in cultured rat ca...
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Article
Cross-talk between arterioles and tubules in the kidney
In hypertension the pressure natriuresis set point is shifted to a higher pressure due to an increase in both renal vascular resistance and sodium (Na) reabsorption. The afferent arterioles (Af-Arts) and effer...
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Chapter
Kinins in the Heart
Kinins are polypeptides that contain the sequence of the nonapeptide, bradykinin, in their structure. In mammals, the main kinins are bradykinin and lysine-bradykinin. They are generated by a group of enzymes ...
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Chapter
The molecular biology of the kallikrein-kinin system
There are numerous indications that the kallikrein-kinin system is underexpressed in various forms of hypertension: for example, urinary kallikrein excretion is decreased in human essential hypertension and in...
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Chapter
Kininogenase from Rat Vascular Tissue
A kininogenase resembling glandular kallikrein ws partially purified from vascular tissue and characterized. Saline perfused rat tail arteries and veins were homogenized in 0.25 M sucrose containing 10 mM Tris...
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Chapter
Release of Kallikrein and Tonin from the Rat Submandibular Gland
The interaction of neurotransmitters and hormones with specific receptors on the plasma membranes of cells results in enzyme secretion from exocrine glands. However, the effects of agonists on the release of k...
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Chapter
Kallikrein and Kinins Independently Stimulate Renin Release from Isolated Rat Glomeruli
We studied the interaction between kallikrein, kinins, and renin release in isolated rat renal glomeruli and their attendant arterioles. Purified hog kallikrein (170 mEU/ml) significantly stimulated renin rele...
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Chapter
Effect of Sodium Restriction and Corticosteroids on Glandular Kallikrein in Plasma and in the Submandibular Gland
We investigated whether sodium restriction or mineralocorticoid influence the release of submandibulary kallikrein into the blood and/or the concentration of kallikrein in glandular tissue. For this we measure...
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Chapter
The Glandular Kallikrein-Kinin System in Hypertension
Kallikreins are enzymes that release kinins, potent vasodilator peptides from plasma substrates called kininogens. In the microdissected nephron, prekallikrein and kailikrein are localized in the granular part...
