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Article
Gliadin-dependent cytokine production in a bidimensional cellular model of celiac intestinal mucosa
The downstream cascade of the inflammatory response to gliadin in celiac intestinal mucosa encompasses the early activation of the innate immunity that triggers the adaptive response. Therefore, the in vitro s...
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Article
Open AccessDiversity of oat varieties in eliciting the early inflammatory events in celiac disease
Celiac disease (CD) is an autoimmune enteropathy, triggered by dietary gluten. The only treatment is a strict gluten-free diet. Oats are included in the list of gluten-free ingredients by European Regulation,...
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Article
The sourdough fermentation may enhance the recovery from intestinal inflammation of coeliac patients at the early stage of the gluten-free diet
This study aimed at investigating the effect of corn, rice and amaranth gluten-free (GF) sourdoughs on the release of nitric oxide (NO) and synthesis of pro-inflammatory cytokines by duodenal mucosa biopsies o...
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Article
Early tissue transglutaminase–mediated response underlies K562(S)-cell gliadin-dependent agglutination
K562(S) agglutination has been used as a rapid and economic tool for the in vitro screening of the toxicity of cereal fractions and prolamins in celiac disease (CD). A strict correlation has been reported between...
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Article
Two prolamin peptides from durum wheat preclude celiac disease-specific T cell activation by gluten proteins
Celiac disease (CD) is a permanent intolerance to wheat prolamins and related proteins displayed by genetically susceptible individuals. Blocking or modulation of CD-specific T cell response by altered prolami...
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Article
Normal rat intestinal cells IEC-18: characterization and transfection with immortalizing oncogenes
IEC-18 cells, a cell line derived from the ileum of rat intestine, have the characteristics of normal cells since they have a contact inhibited cell growth, do not form colonies in soft agar and are not tumori...
