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  1. No Access

    Reference Work Entry In depth

    Mismatch Repair in Genetic Instability

    Margherita Bignami in Encyclopedia of Cancer (2017)

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    Living Reference Work Entry In depth

    Mismatch Repair in Genetic Instability

    Margherita Bignami in Encyclopedia of Cancer

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    Article

    Phenotypic characterization of missense polymerase-δ mutations using an inducible protein-replacement system

    Next-generation sequencing has revolutionized the search for disease-causing genetic alterations. Unfortunately, the task of distinguishing the handful of causative mutations from rare variants remains dauntin...

    Medini Manohar Ghodgaonkar, Patrick Kehl, Ilenia Ventura, Liyan Hu… in Nature Communications (2014)

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    Reference Work Entry In depth

    Mismatch Repair in Genetic Instability

    Margherita Bignami in Encyclopedia of Cancer (2011)

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    Reference Work Entry In depth

    Mismatch Repair in Genetic Instability

    Margherita Bignami in Encyclopedia of Cancer (2009)

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    Article

    The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase

    In yeast, MSH2 plays an important role in mismatch repair (MMR) and recombination, whereas the function of the mammalian MSH2 protein in recombinational repair is not completely established. We examined the ce...

    Annapaola Franchitto, Pietro Pichierri, Rita Piergentili, Marco Crescenzi… in Oncogene (2003)

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    Reference Work Entry In depth

    Mismatch Repair in Genome Stability

    Margherita Bignami in Encyclopedic Reference of Cancer (2001)

  8. No Access

    Article

    Normal rat intestinal cells IEC-18: characterization and transfection with immortalizing oncogenes

    IEC-18 cells, a cell line derived from the ileum of rat intestine, have the characteristics of normal cells since they have a contact inhibited cell growth, do not form colonies in soft agar and are not tumori...

    Olimpia Vincentini, Carmela Ciotta, Margherita Bignami… in Cytotechnology (1996)

  9. No Access

    Article

    Spontaneous mutations ataprt locus in a mammalian cell line defective in mismatch recognition

    Clone B is a CHO cell line that showns a moderate mutator phenotype as a consequence of a defect in mismatch recognition. To identify the classes of mutation that accumulate spontaneously in a functional gene,...

    Patricia Hess, Gabriele Aquilina, Eugenia Dogliotti… in Somatic Cell and Molecular Genetics (1994)

  10. No Access

    Chapter

    The Role of O6-Alkylguanine in Cell Killing and Sister Chromatid Exchange Induced by Alkylating Agents

    When DNA is exposed to alkylating agents, reactions occur at as many as fifteen different sites on the bases and at the phosphodiester backbone (Beranek, et.al., 1980). The relative proportion of the alkylation p...

    Angelo Abbondandolo, Gabriele Aquilina… in DNA Repair Mechanisms and Their Biological… (1989)

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    Article

    An operon for histidine biosynthesis in Streptomyces coelicolor

    On the assumption that a cluster of five his genes (eight cistrons) in S. coelicolor corresponds to an operon, a genetic analysis of a constitutive mutant was carried out. This strain has a multi-site mutation lo...

    A. Carere, Serena Russi, Margherita Bignami… in Molecular and General Genetics MGG (1973)