-
Article
Open AccessFRMD6 determines the cell fate towards senescence: involvement of the Hippo-YAP-CCN3 axis
Cellular senescence, a hallmark of aging, is pathogenically linked to the development of aging-related diseases. This study demonstrates that FRMD6, an upstream component of the Hippo/YAP signaling cascade, is...
-
Article
Open AccessEpithelioid angiomyolipoma of the liver in a patient with Li-Fraumeni syndrome: a case report
Epithelioid angiomyolipoma (EAML) is a rare variant of angiomyolipoma that predominantly consists of epithelioid cells and belongs to the perivascular epithelioid cell neoplasm (PEComa) family. The majority of...
-
Article
Open AccessMicroRNA 29a therapy for CEACAM6-expressing lung adenocarcinoma
Non-coding microRNAs (miRNAs) play critical roles in tumor progression and hold great promise as therapeutic agents for multiple cancers. MicroRNA 29a (miR-29a) is a tumor suppressor miRNA that inhibits cancer...
-
Article
Open AccessPrediction models for early diagnosis of actinomycotic osteomyelitis of the jaw using machine learning techniques: a preliminary study
This study aimed to develop and validate five machine learning models designed to predict actinomycotic osteomyelitis of the jaw. Furthermore, this study determined the relative importance of the predictive va...
-
Article
pSlugS158 immunohistochemistry is a novel promising mitotic marker for FFPE samples: a pilot study
Slug is a transcription factor belonging to the slug/snail superfamily. The protein is involved in embryonic development and epithelial-mesenchymal transition of tumors. Slug is also under temporal regulation ...
-
Article
Open AccessAge-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets
While the seroprevalence of SARS-CoV-2 in healthy people does not differ significantly among age groups, those aged 65 years or older exhibit strikingly higher COVID-19 mortality compared to younger individual...
-
Article
Open AccessDiscordance in HER2 status between primary gastric adenocarcinoma tumors and cells from the corresponding malignant effusions
Metastasis of gastric cancer commonly manifests as a malignant effusion, which presents an alternative cell source for human epidermal growth factor receptor 2 (HER2) status identification. This study aimed to...
-
Article
Open AccessTherapeutic Effect of pHLIP-mediated CEACAM6 Gene Silencing in Lung Adenocarcinoma
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) plays an important role in lung cancer progression. Here, we examined the therapeutic efficacy of CEACAM6 gene silencing using an siRNA delivery...
-
Article
The p21-activated kinase 4-Slug transcription factor axis promotes epithelial−mesenchymal transition and worsens prognosis in prostate cancer
Epithelial−mesenchymal transition (EMT) facilitates cancer invasion and metastasis and thus accelerates cancer progression. p21-activated kinase 4 (PAK4) is a critical regulator of prostate cancer (PC) progres...
-
Article
Secondary adult encephalocele with abscess formation of calcified frontal sinus mucocele
Although encephalocele is a rare congenital abnormality, secondary encephalocele is extremely rare and can cause fatal complications. Here, we report a case of secondary encephalocele caused by frontal sinus w...
-
Article
Open AccessCEACAM6 as detected by the AP11 antibody is a marker notable for mucin-producing adenocarcinomas
A new monoclonal antibody recognizing CEACAM6, which we named AP11, was generated by immunizing BALB/c mice with phytohemagglutinin-activated human peripheral blood mononuclear cells. This study aims to evalua...
-
Article
Open AccessPneumatosis intestinalis and portal venous gas secondary to Gefitinib therapy for lung adenocarcinoma
Pneumatosis intestinalis (PI), defined as the presence of gas in the bowel wall, and portal venous gas (PVG) are relatively rare radiological findings. Although several chemotherapeutic agents and anti-vascula...
-
Article
Gallbladder metastasis of non-small cell lung cancer presenting as acute cholecystitis
Although non-small cell lung cancer (NSCLC) can metastasize to almost any organ, metastasis to the gallbladder with significant clinical manifestation is relatively rare. Here, we report a case of gallbladder ...
-
Article
Molecular characterization and phylogenetic analysis of H3N2 human influenza A viruses in Cheongju, South Korea
To investigate the genetic characteristics of human influenza viruses circulating in Chungbuk province, we tested 510 clinical samples of nasopharyngeal suction from pediatric patients diagnosed with respirato...
