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  1. No Access

    Article

    Investigation of 3,5-Isoxazolidinediones as Hypolipidemic Agents in Rodents

    A series of 2-benzoyl-4,4-dialkyl-3,5-isoxazolidinediones proved to have potent hypolipidemic activity, lowering both serum cholesterol and triglyceride levels at 10 or 20 mg/kg/day, IP and orally in rodents. ...

    Tyrone Woodard, Manik L. Debnath, Rupendra Simlot… in Pharmaceutical Research (1995)

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    Article

    Structure activity relationships of imidoN-alkyl semicarbazones, thiosemicarbazones and acethydrazones as hypolipidemic agents in rodents

    A series of nitrogen substitutedN-butan-3-one derivatives of cyclic imides (phthalimide, substituted phthalimide,o-benzosulfimide, 1,8-naphthalimide, 2,3-dihydrophthalazine-1,4-dione and diphenimide) and their se...

    James M. Chapman Jr., Pierre DeLucy, Oi T. Wong, Iris H. Hall in Lipids (1990)

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    Article

    The Hypolipidemic Activity of l-N-3-Methylphthalimido-butan-3-semicarbazone in Rodents

    l-N-(3-Methylphthalimido)butan-3-one semicarbazone demonstrated potent hypolipidemic activity in normal rats and mice and hyperlipidemic diet-induced mice. The compound decreased tissue lipid levels and increased...

    Oi T. Wong, Iris H. Hall, James M. Chapman Jr in Pharmaceutical Research (1989)

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    Article

    The Effects of Phthalimide and Saccharin Derivatives on Low-Density Lipoprotein (LDL) and High-Density Lipoprotein (HDL) Receptor Activity and Related Enzyme Activities

    The hypolipidemic agents, phthalimide, saccharin, o-(N-phthalimido) acetophenone, N-(p-chlorobenzoyl) sulfamate, and o-chlorobenzylsulfonamide affected low-density lipoprotein (LDL) and high-density lipoprotein (...

    Iris H. Hall, Oi T. Wong, Steven D. Wyrick in Pharmaceutical Research (1988)

  5. No Access

    Article

    Hypolipidemic Activity of o-(N-Phthalimido)acetophenone in Sprague Dawley Rats

    o-(N-Phthalimido)acetophenone has proven to be an effective hypolipidemic agent in rats at 20 mg/kg/ day orally. The agent suppressed the activity of the rate-limiting enzyme of the liver involved in de novo syn...

    Iris H. Hall, David J. Reynolds, Oi T. Wong, C. Brent Oswald… in Pharmaceutical Research (1987)

  6. No Access

    Article

    Synthesis and Hypolipidemic Activity of 3-Imino-l-oxoisoindolines in Rodents

    A series of substituted 3-imino-l-oxoisoindolines derivatives demonstrated significant hypolipidemic activity, lowering both serum cholesterol and triglycerides levels after 16 days of dosing at 20 mg/kg/ day ...

    Akula R. K. Murthy, Oi T. Wong, David J. Reynolds, Iris H. Hall in Pharmaceutical Research (1987)