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Article
Effects of 2-(2,4-dimethylphenyl)indan-1,3-dione on serum lipoprotein and lipid metabolism of rodents
2-(2,4-Dimethylphenyl)indan-1,3-dione was shown to be a potent hypolipidemic agent in rodents, lowering significantly both serum cholesterol and triglyceride levels at 20 mg/kg/day. The agent in vivo inhibited...
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Article
Hypolipidemic Activity of o-(N-Phthalimido)acetophenone in Sprague Dawley Rats
o-(N-Phthalimido)acetophenone has proven to be an effective hypolipidemic agent in rats at 20 mg/kg/ day orally. The agent suppressed the activity of the rate-limiting enzyme of the liver involved in de novo syn...
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Article
Synthesis and Hypolipidemic Activity of 3-Imino-l-oxoisoindolines in Rodents
A series of substituted 3-imino-l-oxoisoindolines derivatives demonstrated significant hypolipidemic activity, lowering both serum cholesterol and triglycerides levels after 16 days of dosing at 20 mg/kg/ day ...
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Article
The Synthesis of Homophthalimide and Related Derivatives and Their Hypolipidemic Activity in Rodents
Homophthalimide and a series of N-alkyl-substituted derivatives were investigated to determine their ability to lower serum cholesterol and triglyceride levels in mice. At 20 mg/kg/day these agents were equall...
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Article
Hypolipidemic activity of 3- and 4-phenyl-piperidine-2,6-diones and selected N-substituted derivatives
Three- and 4-phenyl-piperidine-2,6-dione derivatives were investigated for hypolipidemic activity at 20 mg/kg/day intraperitoneally in rodents. The 3-phenyl compound afforded the best activity and effectivenes...
