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Article
Substantial improvement of histopathological diagnosis by whole-slide image-based remote consultation
Consultation by subspecialty experts is the most common mode of rendering diagnosis in challenging cases in pathological practice. Our study aimed to highlight the diagnostic benefits of whole-slide image (WSI...
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Article
Open AccessPrognostic value of tumor-infiltrating B lymphocytes and plasma cells in triple-negative breast cancer
Recent investigations have demonstrated that the tumor microenvironment, including tumor-infiltrating lymphocytes (TILs), is an important factor in tumor growth and development. While the prognostic correlatio...
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Article
Open AccessTumor-infiltrating B cells and T cells correlate with postoperative prognosis in triple-negative carcinoma of the breast
In this study, we investigated CD20+ TILs in triple-negative breast cancer (TNBC) and their relationship with T lymphocyte subsets (CD4+, CD8+, CD25+, and FOXP3+), including their combined prognostic value usi...
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Article
Open AccessTargeted next-generation sequencing assays using triplet samples of normal breast tissue, primary breast cancer, and recurrent/metastatic lesions
Next-generation sequencing (NGS) has shown that recurrent/metastatic breast cancer lesions may have additional genetic changes compared with the primary tumor. These additional changes may be related to tumor ...
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Article
Open AccessOestrogen receptor-negative/progesterone receptor-positive phenotype of invasive breast carcinoma in Japan: re-evaluated using immunohistochemical staining
The existence of progesterone receptor (PgR) expression in oestrogen receptor (ER)-negative breast carcinoma is controversial. Here, we re-evaluated ER-negative/PgR-positive (ER−/PgR+) carcinoma cases by immun...
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Article
Spermatocytic seminoma in a 92-year-old man: report of a case in which SALL4, a potential novel marker for testicular germ cell tumors, was useful for the diagnosis
Spermatocytic seminoma (SS) is a rare testicular germ cell tumor (TGCT), occurring exclusively in the testes. Diagnosis of SS is important because, unlike other testicular tumors, SS must be treated by orchiec...
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Article
Roles of fine-needle aspiration and core needle biopsy in the diagnosis of breast cancer
There is controversy regarding which of the two biopsy methods, fine-needle aspiration (FNA) or core needle biopsy (CNB), should be routinely employed for diagnosis of breast cancer. The aim of this study was ...
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Article
Immunohistochemical localization of sodium–potassium ATPase in human normal stomach and gastric adenocarcinomas
We studied the expression pattern of Na, K-ATPase β1 subunit in human normal stomachs and in gastric adenocarcinomas by using anti-Na, K-ATPase β1 subunit-specific monoclonal antibody. Tissue samples were proc...
