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Article
Altered expression of CDX-2, PDX-1 and mucin core proteins in “Ulcer-associated cell lineage (UACL)” in Crohn’s disease
The ulcer-associated cell lineage (UACL) induced at the site of ileac chronic ulceration in Crohn’s disease has been reported to show histological differentiation resembling gastric pyloric mucosa. To clarify ...
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Article
Histochemical, ultrastructural, and three-dimensional observation of smooth muscle cells in human gastric mucosa
The present study was undertaken to clarify the histochemical and ultrastructural properties and the three-dimensional distribution of the smooth muscle cells (SMCs) located in the lamina propria (LP) of the h...
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Article
Immunohistochemical localization of sodium–potassium ATPase in human normal stomach and gastric adenocarcinomas
We studied the expression pattern of Na, K-ATPase β1 subunit in human normal stomachs and in gastric adenocarcinomas by using anti-Na, K-ATPase β1 subunit-specific monoclonal antibody. Tissue samples were proc...
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Article
Three-dimensional analysis of alveolar structure in usual interstitial pneumonia
The etiology of usual interstitial pneumonia (UIP), a progressive lung disease, remains unclear. We examined alveolar structure in UIP three-dimensionally. Lung biopsy specimens from five patients with idiopa...
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Article
Histone H3 MRNA in situ Hybridization for Identifying Proliferating Cells in Human Pancreas, with Special Reference to the Ductal System
In general, the incidence of proliferating cells parallels that of carcinogenesis. We have investigated proliferating activity and phenotype expression in epithelial cells in normal tissue, mucinous metaplasia...
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Article
Helicobacter pylori infection produces expression of a secretory component in gastric mucous cells
Helicobacter pylori infection induces the expression of a secretory component (SC) in gastric epithelial cells. We investigated the cell lineage of the SC- and immunoglobulin (Ig) A-expr...
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Article
Helicobacter pylori infection produces reversible glycosylation changes to gastric mucins
The protective ability of gastric mucins may depend largely on their oligosaccharide chains. We evaluated the effects of H. pylori infection on the glycosylation of gastric mucins. Gastric biopsy specimens from ...
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Article
Differential expression of moesin in cells of hematopoietic lineage and lymphatic systems
Moesin is a member of the ERM family consisting of ezrin, radixin, and moesin. The protein is located in the plasma membrane similarly to ezrin and radixin, and is thought to regulate cellular movements and m...
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Article
The application of immunoperoxidase staining for the detection of causative fungi in tissue specimens of mycosis I
This study was performed in order to identify the fungi of four species (Aspergillus fumigatus, Fusarium anthophilum, Candida albicans, Cryptococcus neoformans) in formalin-fixed, paraffin-embedded tissue section...