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    Application of primary hepatocyte sandwich cultures for predictive studies of drug metabolism and precarcinogen activation

    Loss of cytochrome P450 content is a common feature in conventional culture systems of primary hepatocytes. In vivo each hepatocyte is exposed to an extracellular matrix (space of Disse) at two opposing basolater...

    A. Bader, R. Fahrig, A. Steinkamp, N. Frühauf, O. Crome, K. Zech… in Animal Cell Technology (1997)