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Article
Open AccessCorrelation between hemoglobin and the risk of common malignant tumors: a 1999–2020 retrospective analysis and causal association analysis
The role of hemoglobin (HGB) in common malignant tumors remains unclear.
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Article
Open AccessNovel NARS2 variants in a patient with early-onset status epilepticus: case study and literature review
NARS2 as a member of aminoacyl-tRNA synthetases was necessary to covalently join a specific tRNA to its cognate amino acid. Biallelic variants in NARS2 were reported with disorders such as Leigh syndrome, deafnes...
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Article
A nosocomial Pseudomonas aeruginosa ST3495 isolated from a wild Burmese python (Python bivittatus) with suppurative pneumonia and bacteremia in Hainan, China
Pseudomonas aeruginosa is a common infectious agent associated with respiratory diseases in boas and pythons, however, the histopathology, resistance and virulence are yet described for this species. In this stud...
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Article
Open AccessStrong immune responses and protection of PcrV and OprF-I mRNA vaccine candidates against Pseudomonas aeruginosa
Pseudomonas aeruginosa (PA) is a leading cause of hospital-acquired and ventilator-associated pneumonia. The multidrug-resistance (MDR) rate of PA is increasing making the management of PA a global challenge. Mes...
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Pain Disorders
Chronic pain is mainly divided into two categories: neuropathic pain and nociceptive pain. Chronic visceral pain and migraine are separately discussed in this chapter due to their unclear pathological mechanis...
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Article
Emerging theory and phenomena in thermal conduction: A selective review
Recently, emerging phonon phenomena have been discovered and rapidly developed, which have become an active hot research topic. In this review article, we present state-of-the-art advances in several fascinati...
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Article
Open AccessGeneration of in situ CRISPR-mediated primary and metastatic cancer from monkey liver
Non-human primates (NHPs) represent the most valuable animals for drug discovery. However, the current main challenge remains that the NHP has not yet been used to develop an efficient translational medicine p...
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Article
A double-locus scarless genome editing system in Escherichia coli
To develop a convenient double-locus scarless genome editing system in Escherichia coli, based on the type II Streptococcus pyogenes CRISPR/Cas9 and λ Red recombination cassette.
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Article
Open AccessAn Efficient Cell-Targeting Drug Delivery System Based on Aptamer-Modified Mesoporous Silica Nanoparticles
How to deliver chemotherapeutic drugs efficiently and selectively to tumor cells to improve therapeutic efficacy remains a difficult problem. We herein construct an efficient cell-targeting drug delivery syste...
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Article
NTRK1 is a positive regulator of YAP oncogenic function
Multiple cancer signalling networks take part in regulatory crosstalks with the Hippo tumour suppressor pathway through the transcriptional cofactor Yes-associated protein (YAP). Nevertheless, how YAP is contr...
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Article
Open AccessCorrection to: A Graphene Oxide-Based Fluorescent Aptasensor for the Turn-on Detection of CCRF-CEM
In the original publication of this article [1] the author Li** Zhong was omitted. In this correction article the author and the corresponding details are provided. The publisher apologizes to the readers an...
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Article
Open AccessThe Hippo Signaling Transducer TAZ Regulates Mammary Gland Morphogenesis and Carcinogen-induced Mammary Tumorigenesis
Hippo signaling pathway is an evolutionarily conserved pathway that controls organ size by regulating cell proliferation, apoptosis and stem cell self-renewal. TAZ (transcriptional coactivator with the PDZ-bin...
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Article
Open AccessA Graphene Oxide-Based Fluorescent Aptasensor for the Turn-on Detection of CCRF-CEM
A convenient, low-cost, and highly sensitive fluorescent aptasensor for detection of leukemia has been developed based on graphene oxide-aptamer complex (GO-apt). Graphene oxide (GO) can absorb carboxyfluoresc...
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Article
Enhancement of Thermal Conductivity of Polyvinyl Alcohol Membrane Using Nano-fiber
The thermal properties of organic membranes attract much attention due to the fact that heat dissipation in electronic devices limits their functionality and reliability. Here, we enhance the thermal conductiv...
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Article
Open AccessVGLL4 Selectively Represses YAP-Dependent Gene Induction and Tumorigenic Phenotypes in Breast Cancer
Members of the mammalian Vestigial-like (VGLL) family of transcriptional cofactors activate genes in response to a wide variety of environmental cues. Recently, VGLL proteins have been proposed to regulate key...
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Article
Open AccessAssociation Between BMI and Recurrence of Primary Spontaneous Pneumothorax
Whether body mass index (BMI) is a significant risk factor for recurrence of primary spontaneous pneumothorax (PSP) remains controversial. The purpose of this study was to examine whether BMI and other factors...
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Article
Open AccessAptamer Combined with Fluorescent Silica Nanoparticles for Detection of Hepatoma Cells
The purpose of this study is to develop a simple, effective method to label hepatoma cells with aptamers and then detect them using fluorescent silica nanoparticles (FSNPs).
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Article
Open AccessClinical study of a survivin long peptide vaccine (SurVaxM) in patients with recurrent malignant glioma
Survivin is an anti-apoptotic protein that is highly expressed in many cancers, including malignant gliomas. Preclinical studies established that the conjugated survivin peptide mimic SurVaxM (SVN53-67/M57-KLH...
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Article
Open AccessAptamer-Functionalized Fluorescent Silica Nanoparticles for Highly Sensitive Detection of Leukemia Cells
A simple, highly sensitive method to detect leukemia cells has been developed based on aptamer-modified fluorescent silica nanoparticles (FSNPs). In this strategy, the amine-labeled Sgc8 aptamer was conjugated...
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Article
Open AccessSpontaneous Migration of Polyethylene Molecule Sheathed inside Single-Walled Carbon Nanotube for Nano-Heat Pipe
Development of nanoscale thermal exchanging devices is critical to thermal management in nanoscale. The spontaneous migration of polyethylene molecule sheathed inside single-walled carbon nanotube (SWCNT) are ...
