21 Result(s)
within
Robert A. Fenstermaker
-
Article
Open AccessBevacizumab and gamma knife radiosurgery for first-recurrence glioblastoma
Glioblastoma (GBM) is the most common central nervous system malignancy in adults. Despite decades of developments in surgical management, radiation treatment, chemotherapy, and tumor treating field therapy, G...
-
Article
Meta-analysis of overall survival and postoperative neurologic deficits after resection or biopsy of butterfly glioblastoma
Butterfly glioblastoma (bGBM) is a grade 4 glioma with a poor prognosis. Surgical treatment of these cancers has been reviewed in the literature with some recent studies supporting resection as a safe and effe...
-
Article
Primary Leiomyosarcoma of the Calvarium with Intracranial Extension: a Case Report
-
Article
Disparities among racial/ethnic groups of patients diagnosed with ependymoma: analyses from the Surveillance, Epidemiology and End Results (SEER) registry
The aim of this study was to identify racial/ethnic disparities with regard to survival among patients with ependymoma.
-
Article
KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma
A major challenge to develo** new therapies for patients with malignant brain tumors is that relatively few small molecule anticancer drugs penetrate the blood–brain barrier (BBB) well enough to provide ther...
-
Article
Brain and hippocampal doses in patients with repeated stereotactic radiosurgery for brain metastasis
The study was designed to evaluate the cumulative dose exposure of brain and hippocampus following multiple stereotactic radiosurgery (SRS) procedures on a single patient.
-
Article
Open AccessClinical study of a survivin long peptide vaccine (SurVaxM) in patients with recurrent malignant glioma
Survivin is an anti-apoptotic protein that is highly expressed in many cancers, including malignant gliomas. Preclinical studies established that the conjugated survivin peptide mimic SurVaxM (SVN53-67/M57-KLH...
-
Article
Radiologic response to radiation therapy concurrent with temozolomide for progressive simple dysembryoplastic neuroepithelial tumor
Dysembryoplastic neuroepithelial tumors (DNETs) are low-grade neuroglial tumors that are traditionally considered to be benign hamartoma-like mass lesions. Malignant transformation and disease progression have...
-
Article
Antitumor cytotoxic T-cell response induced by a survivin peptide mimic
Survivin is a tumor-associated antigen with significant potential as a cancer vaccine target. We have identified a survivin peptide mimic containing human MHC class I epitopes and a potential class II ligand t...
-
Article
Convection enhanced delivery of boronated EGF as a molecular targeting agent for neutron capture therapy of brain tumors
In the present study, we have evaluated a boronated dendrimer-epidermal growth factor (BD-EGF) bioconjugate as a molecular targeting agent for boron neutron capture therapy (BNCT) of the human EGFR gene-transf...
-
Article
Expression of HMP/AN2, a melanoma associated antigen, in murine cerebral gliomas: potential for radioimmunotargeting
Human melanoma proteoglycan (HMP), a melanoma-associated antigen, is expressed in both human melanomas and gliomas. We used HMP-specific monoclonal antibody (mAb) VT68.2 to investigate whether murine GL261 cer...
-
Article
Therapeutic effect of a T helper cell supported CTL response induced by a survivin peptide vaccine against murine cerebral glioma
Survivin is a tumor-associated antigen (TAA) that has significant potential for use as a cancer vaccine target. To identify survivin epitopes that might serve as targets for CTL-mediated, anti-tumor responses,...
-
Article
Antitumor effects of a xenogeneic survivin bone marrow derived dendritic cell vaccine against murine GL261 gliomas
Survivin is a member of the inhibitor of apoptosis protein family. Gliomas and many other tumors express survivin at high levels; whereas, normal fully differentiated cells generally do not. Therefore, survivi...
-
Article
Cellular antitumor immune response to a branched lysine multiple antigenic peptide containing epitopes of a common tumor-specific antigen in a rat glioma model
Human malignant gliomas contain epidermal growth factor receptor (EGFR) gene mutations that encode tumor-associated antigens (TAAs) that can be targeted using immunological techniques. One EGFR mutant gene (EG...
-
Article
Melanotic schwannoma with drop metastases to the caudal spine and high expression of CD117 (c-kit)
Melanotic schwannomas (MS) are tumors of Schwann cell origin characterized by cytoplasmic deposition of melanin. The authors present the case of a 61-year-old man who experienced progressive weakness of the lo...
-
Article
Evaluation of Systemically Administered Radiolabeled Epidermal growth Factor as a Brain Tumor Targeting Agent
We have previously reported a method for labeling epidermal growth factor (EGF) with technetium-99m and have shown that 99mTc-EGF localized in EGF receptor (R) positive intracerebral C6EGFR rat gliomas following ...
-
Article
Deletion and tandem duplication of exons 2–7 in the epidermal growth factor receptor gene of a human malignant glioma
The epidermal growth factor receptor (EGFR) gene is frequently amplified and rearranged in malignant gliomas with expression of oncogenic deletion mutants (DM). The most common mutant EGFRvIII, which contains ...
-
Article
Oncogenic epidermal growth factor receptor mutants with tandem duplication: gene structure and effects on receptor function
A number of epidermal growth factor receptor (EGFR) deletion mutants have been identified in gliomas, in which the EGFR gene is frequently amplified and rearranged. We have previously characterized the structu...
-
Article
Synergistic Cytotoxicity, Apoptosis and Protein-linked DNA Breakage by Etoposide and Camptothecin in Human U87 Glioma Cells: Dependence on Tyrosine Phosphorylation
In this study, simultaneous administration of certain inhibitors of topoisomerase I and topoisomerase II produced synergistic cytotoxicity in a series of human glioma cell lines. Camptothecin (CPT) and etoposi...
-
Article
Intratumoral infusion of topotecan prolongs survival in the nude rat intracranial U87 human glioma model
Topotecan is a topoisomerase (topo) I inhibitor with promising activity in preclinical studies. We hypothesized that low-dose intratumoral delivery of topotecan would be highly effective for gliomas. Human gli...
