20 Result(s)

Chapter

Hematopoietic Tumors: Normal or Abnormal Models of Leukocyte Differentiation?

One of the major problems in cellular immunobiology has been the issue of resolving the cellular bases of the many different specific functional properties mediated by the immune system. This is in essence a d...

Noel L. Warner, Lewis L. Lanier, Edwin Walker… in Hybridomas and Cellular Immortality (1983)

Article

Flow cytometry analysis of T cells and continuous T-cell lines from autoimmune MRL/l mice

The study of spontaneous autoimmunity in mouse models affords an opportunity to determine the cellular basis of the immune dysregulation observed in this disease. Recently, a new mouse strain, MRL/Mp-lpr/lpr (MRL...

D. E. Lewis, J. V. Giorgi, Noel L. Warner in Nature (1981)

Article

Immunoglobulin isoantigens (allotypes) in the mouse

Murine antisera raised against allogeneic lymphoid cells often contain antibodies to IgM allotypes. Rarely, allotypic antibodies to IgM have been found after immunization withB. pertussis anti-B. pertussis conjug...

Samuel J. Black, James W. Goding, George A. Gutman, Leonard A. Herzenberg… in Immunogenetics (1978)

Chapter

Lymphocyte Differentiation as Analyzed by the Expression of Defined Cell Surface Markers

The general subject of this presentation concerns aspects of lymphocyte differentiation as analyzed through the use of murine lymphomas. It might first be questioned whether this general topic has particular r...

Noel L. Warner, Alan W. Harris… in Immunobiology of Proteins and Peptides · I (1978)

Chapter

In Vitro Induction and Expression of T-Cell Immunity to Tumor-Associated Antigens

The development of in vitro assays of cell-mediated cytotoxicity has provided a means both of quantitating cell-mediated immunity (CMI) induced in vivo, and also of identifying thecytotoxic effector cells (CL) in...

Robert C. Burton, Stanley E. Chism, Noel L. Warner in Contemporary Topics in Immunobiology (1978)

Article

In vitro induction of tumor-specific immunity. IV. Specific adoptive immunotherapy with cytotoxic T cells induced in vitro to plasmacytoma antigens

Specifically activated cytotoxic T cells (CL's) were raised by cocultivation in vitro of normal spleen cells with syngeneic plasmacytoma cells. These CL's were fully active both in vitro in lysing ⁵¹Cr-labelled t...

Robert C. Burton, Noel L. Warner in Cancer Immunology, Immunotherapy (1977)

Article

Allotypes of mouse IgM immunoglobulin

GENETIC polymorphism of the structural genes encoding the class-specific (heavy) polypeptide chains of the immunoglobulin (Ig) molecules provides a useful set of markers for elucidating the arrangement and exp...

NOEL L. WARNER, JAMES W. GODING, GEORGE A. GUTMAN, GREGORY W. WARR… in Nature (1977)

Article

Autoimmunity and the pathogenesis of plasma cell tumor induction in NZB inbred and hybrid mice

Noel L. Warner in Immunogenetics (1975)

Article

Helper effect of normal and irradiated thymus cells on transferred immunoglobulin production

THE cellular transfer of immunoglobulin (Ig) production in mice by various lymphoid cell preparations has been demonstrated previously by the use of allotype congenic mouse strains^1,2. Lymphoid cell suspensions f...

NOEL L. WARNER, ROBERT E. ANDERSON in Nature (1975)

Chapter and Conference Paper

Immunoglobulin Gene Expression in Murine Lymphoid Cells

Immune responses of all types depend fundamentally on the expression of immunoglobulin structural genes in lymphoid cells. The complete in vivo manifestation of the various types of immunity, such as delayed hype...

Noel L. Warner, Alan W. Harris in The Biochemistry of Gene Expression in Higher Organisms (1973)

Chapter

Surface Immunoglobulins on Lymphoid Cells

The initiation of an immune response requires the direct interaction of the specific antigen with a lymphocyte. In some immune responses, macrophages play an obligatory role in handling the antigen; in others,...

Noel L. Warner in Contemporary Topics in Immunobiology (1972)

Chapter

Immunoglobulin Gene Expression in Immunocyte Differentiation

Immunocompetent cells appear to exist in at least two distinct subpopulations on the basis of several different observations. (i) In chickens, a sharp dichotomy between lymphoid cells involved in cellular or h...

Noel L. Warner, John M. Dwyer in Morphological and Functional Aspects of Immunity (1971)

Article

Blocking of the Lymphocyte Antigen Receptor Site with Anti-immunoglobulin Sera in vitro

ALTHOUGH the events occurring during the induction of an antibody response are not clearly understood, it is evident that antigen must react with some type of receptor which is either free in serum or present ...

NOEL L. WARNER, PAULINE BYRT, G. L. ADA in Nature (1970)

Chapter

Genetics of Immunoglobulins

The introduction of a foreign protein or antigenic material into any vertebrate organism rapidly results in the development of an immune response which is specifically directed toward that particular antigen. ...

H. Hugh Fudenberg, Noel L. Warner in Advances in Human Genetics 1 (1970)

Article

Dissociation of Skin Homograft Tolerance and Donor Type Gamma Globulin Synthesis in Allogeneic Mouse Radiation Chimaeras

NOEL L. WARNER, LEONARD A. HERZENBERG, LEONARD J. COLE, WILLIAM E. DAVIS jun. in Nature (1965)

Article

Gamma-globulin Synthesis in Hormonally Bursectomized Chickens

IN previous investigations it has been found that the normal development of the bursa of Fabricius in chickens is essential if the bird is to develop fully its potential antibody-forming capacity^1–3. In these inv...

J. CAREY, NOEL L. WARNER in Nature (1964)

Article

Immunological Reactivity of Bursaless Chickens in Graft Versus Host Reactions

NOEL L. WARNER, A. SZENBERG in Nature (1963)