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Article
Open AccessAppropriate definition of non-metastatic castration-resistant prostate cancer (nmCRPC) and optimal timing of androgen receptor signaling inhibitor (ARSI)
Defined by rising PSA levels under androgen deprivation therapy (ADT) despite no visible metastases on conventional imaging, non-metastatic castration-resistant prostate cancer (nmCRPC) represents a complex cl...
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Article
Open AccessPRMT5-mediated methylation of STAT3 is required for lung cancer stem cell maintenance and tumour growth
STAT3 is constitutively activated in many cancer types, including lung cancer, and can induce cancer cell proliferation and cancer stem cell (CSC) maintenance. STAT3 is activated by tyrosine kinases, such as J...
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Article
Open AccessRisk factors for postoperative fever after laparoscopic adrenalectomy focusing on hormones produced: a case control study
Laparoscopic adrenalectomy is widely performed for a number of hormone-producing tumors and postoperative management depends on the hormones produced. In the present study, we conducted a retrospective analysi...
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Article
Prediction of pathological up-staging after radical nephroureterectomy in patients with upper tract urothelial carcinoma
The diagnostic accuracy of computed tomography urography for upper tract urothelial carcinoma is high; however, difficulties are associated with precisely assessing the T stage. Preoperative tumor staging has ...
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Article
Open AccessAnemia in patients ≥ 75 years with metastatic clear cell renal cell carcinoma: an important poor prognostic factor in the international metastatic renal cell carcinoma database consortium model
Due to an increase in life expectancy, the incidence of metastatic renal cell carcinoma (mRCC) in patients aged ≥75 years has been increasing. In this study we investigated the characteristics before treatment...
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Article
Prognostic impact of tumor ureteral invasion on recurrence after radical cystectomy
Several preoperative factors have been suggested to be risk factors of disease recurrence after radical cystectomy. There is no study focusing on the impact on prognosis of bladder tumor ureteral invasion in p...
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Article
Open AccessThe HEDGEHOG-GLI1 pathway is important for fibroproliferative properties in keloids and as a candidate therapeutic target
Keloids are benign fibroproliferative skin tumors caused by aberrant wound healing that can negatively impact patient quality of life. The lack of animal models has limited research on pathogenesis or developi...
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Article
Open AccessLoss of p53 function promotes DNA damage-induced formation of nuclear actin filaments
Tumor suppressor p53 plays a central role in response to DNA damage. DNA-damaging agents modulate nuclear actin dynamics, influencing cell behaviors; however, whether p53 affects the formation of nuclear actin...
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Article
Open AccessRange shift and introgression of three Japanese Abies species: insights from population genetic data and species distribution modeling
Range shifts during the Pleistocene shaped the unique phylogeographical structures of many species. Pleistocene range shifts gave currently allopatric species opportunities to occur in sympatry, likely resulti...
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Article
Open AccessRelationship between human behavior and indoor air quality of private room in a care facility for the elderly in Japan
In Japan, the number of elderly people in need of nursing care is increasing while the population of young people is decreasing, and the potential for labor shortages in the field of elder care is of great con...
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Article
Factors affecting the selection of eligible candidates for focal therapy for prostate cancer
Focal therapy (FT) is a treatment modality for prostate cancer that aims to reduce side effects. However, it remains difficult to select eligible candidates. We herein examined eligibility factors for hemi-abl...
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Article
Prognostic role of the innate immune signature CD163 and “eat me” signal calreticulin in clear cell renal cell carcinoma
The effects of the innate immune status on patients with clear cell renal cell carcinoma (ccRCC) currently remain unknown. We herein provided more extensive information about the inner landscape of immunobiolo...
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Article
Strategy for PSA progression in patients undergoing salvage radiation for biochemical recurrence after radical prostatectomy
The treatment strategy for prostate-specific antigen (PSA) progression in patients who receive salvage radiation therapy (RT) for biochemical recurrence (BCR) after radical prostatectomy (RP) is salvage andro...
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Production of Sulfuric Acid and Hydrogen Iodine by Bunsen Reaction Assisted with Membrane
The Bunsen reaction assisted with membrane was carried out to skip the separation processes after the reaction. In order to improve the reaction efficiency, the radiation-grafted cation exchange membrane (CEM)...
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Article
Open AccessDifferential diagnosis of infectious diseases, drug-induced lung injury, and pulmonary infiltration due to underlying malignancy in patients with hematological malignancy using HRCT
To differentiate among infectious diseases, drug-induced lung injury (DILI) and pulmonary infiltration due to underlying malignancy (PIUM) based on high-resolution computed tomographic (HRCT) findings from pat...
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Article
Open AccessIMAGENE trial: multicenter, proof-of-concept, phase II study evaluating the efficacy and safety of combination therapy of niraparib with PD-1 inhibitor in solid cancer patients with homologous recombination repair genes mutation
Previous clinical trials have demonstrated the potential efficacy of poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis) in patients with cancer involving homologous recombination repair (HRR) gene-mutatio...
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Article
A low subcutaneous fat mass is a risk factor for the development of inguinal hernia after radical prostatectomy
Inguinal hernia (IH) after radical prostatectomy (RP) is a complication that impairs quality of life; however, the factors contributing to IH after RP remain unclear. Therefore, we herein attempted to identify...
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Article
Hybridisation chain reaction-based visualisation and screening for lncRNA profiles in clear-cell renal-cell carcinoma
Analysis of long noncoding RNA (lncRNA) localisation at both the tissue and subcellular levels can provide important insights into the cell types that are important for their function.
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Article
Open AccessEmissions of Volatile Organic Compounds from Dairy Cattle Manure in a Cattle Shed in Japan
The livestock industry is a major source of atmospheric volatile organic compounds(VOCs), but details on these emissions are not well documented in Japan. In particular, it remains unclear how the rearing meth...
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Article
Open AccessHigh-resolution CT findings of pulmonary infections in patients with hematologic malignancy: comparison between patients with or without hematopoietic stem cell transplantation
To evaluate the high-resolution CT (HRCT) findings of pulmonary infections in patients with hematologic malignancy and compare them between patients with or without hematopoietic stem cell transplantation (HSCT).
