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Article
Citrate enhances the protective effect of orally administered bismuth subnitrate against the nephrotoxicity ofcis-diamminedichloroplatinum
Attenuation of the renal toxicity ofcis-diamminedichloroplatinum (CDDP) is important in the use of this effective but cytotoxic anticancer agent. We have previously shown that the renal toxicity of CDDP can be ef...
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Article
Citrate enhances the protective effect of orally administered bismuth subnitrate against the nephrotoxicity of cis-diamminedichloroplatinum
Attenuation of the renal toxicity of cis-diamminedichloroplatinum (CDDP) is important in the use of this effective but cytotoxic anticancer agent. We have previously shown that the renal toxicity of CDDP can be e...
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Chapter
Expression Of Cycloxygenase-2 In Human Bladder And Renal Cell Carcinoma
Cyclooxygenase (COX) catalyses the synthesis of prostaglandins from arachidonic acid. There are two isoforms of COX (DuBois et al., 1998; vane et al., 1998). One is constitutively expressed (COX-1) and the oth...
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Article
Glutathione content is correlated with the sensitivity of lines of PC12 cells to cisplatin without a corresponding change in the accumulation of platinum
A study of the involvement of glutathione (GSH) in cellular resistance to cisplatin was performed using methylmercury-resistant sublines (PC12/TM series) of the PC12 line of rat pheochromocytoma cells. The sev...
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Article
Possible involvement of active oxygen species in selenite toxicity in isolated rat hepatocytes
Mechanisms of selenite cytotoxicity were examined using isolated rat hepatocytes. When selenite was added to a suspension of rat hepatocytes, intracellular reduced glutathione (GSH) was decreased and the oxyge...
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Article
Effect of coadministration of selenite on the toxicity and antitumor activity ofcis-diamminedichloroplatinum(II) given repeatedly to mice
The effect of selenite coadministration on the toxicity and antitumor activity of repeated treatment with high doses ofcis-diamminedichloroplatinum (cis-DDP) was examined in mice. Sodium selenite was injected s.c...
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Article
Effect of preinduction of metallothionein on paraquat toxicity in mice
The effect of pretreatment with metallothionein (MT)-inducing metals (Zn, Cu, Bi, Co, Cd or Hg) on paraquat (PQ) toxicity was investigated in mice. PQ lethality was remarkably reduced by pretreatment with the ...
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Book Series
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Book
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Chapter
Role of Glutathione in Mercury Disposition
A complex of methylmercury (MeHg) with glutathione (GSH) has been found in several tissues such as brain, liver, erythrocytes and bile. Although the binding of MeHg to GSH is reversible, the complex formation ...
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Chapter
Microtubules: a Susceptible Target of Methylmercury Cytotoxicity
Alteration of many kinds of cellular functions by methylmercury (MM) exposure in vitro have been reported. However, the causal mechanism for the specific dysfunction of nervous systems has not been clarified yet....
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Article
Effect of bismuth nitrate given in combination withcis-diamminedichloroplatinum(II) on the antitumor activity and renal toxicity of the latter in nude mice inoculated with human bladder tumor
The effects of bismuth nitrate pretreatment on the toxicity and antitumor activity ofcis-diamminedichloroplatinum (cisplatin, CDDP) were examined in nude mice that had been inoculated with human bladder-tumor tis...
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Chapter
Possible Mechanism of Detoxifying Effect of Selenium on the Toxicity of Mercury Compounds
Co-administration of selenium compounds with mercuric mercury resulted in remarkable depression of acute toxicity of mercury through 1) reduction of mercury accumulation in the kidneys, a major target of acute...
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Chapter
Overview
This chapter is an overview of the papers presented at the Tokyo Conference in August, 1990. No references will be quoted as this text is based on the papers presented in this book. At times the names of indiv...
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Chapter and Conference Paper
Trace Elements in Cancer Therapy
We have recently found that selenium, an essential trace element could efficiently depress the adverse side effects of cis-diamminedichloroplatinum (cis-DDP) in mice without compromising its antitumor activity. M...
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Article
Mechanism of cytotoxicity of methylmercury
Mechanism of methylmercury cytotoxicity was investigated with special reference to its preferential action on microtubules and protein biosynthesis in cultured cells. The tubulin synthesis analyzed by autoradi...
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Article
Metallothionein induction prevents toxic side effects of cisplatin and adriamycin used in combination
The protective effects of metallothionein (MT) preinduction by bismuth subnitrate (BSN) against the renal toxicity of cis-diamminedichloroplatinum (cis-DDP), the cardiotoxicity of adriamycin (ADR), and the lethal...
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Article
Physiological role of mercury-methylation inClostridium cochlearium T-2C
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Article
Involvement of mercury methylation in microbial mercury detoxication
A vitamin B12 requiring strain was isolated fromChlostridium cochlearium T-2 C which is known to synthesize various types of vitamin B12 including methylcobalamin and has an ability to methylate inorganic mercury...
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Article
Possible role of membrane proteins in mercury resistance of Enterobacter aerogenes
Mercury resistance shown by a strain of Enterobacter aerogenes was found to be determined by a plasmid. The resistance appeared to be not due to enzymatic volatilization of mercury, but due to the alteration in c...
