Abstract
Cyclooxygenase (COX) catalyses the synthesis of prostaglandins from arachidonic acid. There are two isoforms of COX (DuBois et al., 1998; vane et al., 1998). One is constitutively expressed (COX-1) and the other is inducible (COX-2). The COX-2 gene is an immediate, early-response gene that is induced by growth factors, oncogenes, carcinogens, and tumor-promoting phorbol esters (Inoue et al., 1995; Nanayama et al., 1995; Herschman, 1996). The constitutive isoform, COX-1, is essentially unaffected by these factors.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
DuBois, R.N., Abramson, S.B., Crofford, L., Gupta, R.A., Simon, L.S., van de Putte, L.B., and Lipsky, P.E. 1998. Cyclooxygenase in biology and dieses.FASEB J.12:1063.
Eberhart, C.E., Coffey, R.J., Radhika, A., Giardiello, F.M., Farrenbach, S., and DuBois, R.N. 1994. Up-regulation of cyclooxygenase-2 gene expression in human colorectal adenomas and adenocarcinomas.Gastroenterology107:1183.
Herschman, H.R. 1996. Prostaglandin synthase 2.Biochim. Biophys. Acta1299:125.
one, Y., and Tanabe, T. 1995. Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells: Involvement of both nuclear factor for interleukin-6 expression site and cAMP response element.J. Biol. Chem.270:24965.
Kawamori, T., Rao, C.V., Seibert, K. 1998. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis.Cancer Res.58:409.
Nanayama, T., Hara, S., Inoue, H., Yokoyama, C., and Tanabe, T. 1995. Regulation of two isozymes of prostaglandin endoperoxide synthase and thromboxane synthase in human monoblastoid cell line U937.Prostaglandins.49:371.
Okajima, E., Denda, A., Ozono, S., Takahama, M., Akai, H., Sasaki, Y., Kitayama, W., Wakabayashi, K., and Konishi, Y. 1998. Chemopreventive effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on the development of rat urinary bladder carcinomas initiated by N-butyl-N-(4-hydroxybutyl) nitrosamine.Cancer Res.58:3028.
Reddy, B.S., Rao, C.V., and Seibert, K. 1996. Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis.Cancer Res.56:4566.
Ristimaki, A., Honkanen, N., Jankala, H., Sipponen, P., and Harkonen, M. 1997. Expression of cyclooxygenase-2 in human gastric carcinoma.Cancer Res.57:1276.
Takahashi, M., Fukutake, M., Yokota, S., Ishida, K., Wakabayashi, K., and Sugimura, T. 1996. Supression of azoxymethane-induced aberrant crypt foci in rat colon by nimesulide, a selective inhibitor of cyclooxygenase-2.J. Cancer. Res. Clin. Oncol.122:219.
Vane, J.R., Bakhle, Y.S., and Rotting, R.M. 1998. Cyclooxygenases 1 and 2.Annu. Rev. Pharmacol. Toxicol.38:97.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer Science+Business Media New York
About this chapter
Cite this chapter
Hara, S. et al. (2002). Expression Of Cycloxygenase-2 In Human Bladder And Renal Cell Carcinoma. In: Honn, K.V., Marnett, L.J., Nigam, S., Dennis, E., Serhan, C. (eds) Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5. Advances in Experimental Medicine and Biology, vol 507. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0193-0_20
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0193-0_20
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4960-0
Online ISBN: 978-1-4615-0193-0
eBook Packages: Springer Book Archive