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  1. Article

    Open Access

    Pathway sensor-based functional genomics screening identifies modulators of neuronal activity

    Neuronal signal transduction shapes brain function and malfunction may cause mental disorders. Despite the existence of functional genomics screens for proliferation and toxicity, neuronal signalling has been ...

    Alexander Herholt, Ben Brankatschk, Nirmal Kannaiyan, Sergi Papiol… in Scientific Reports (2018)

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    Article

    Age-related myelin degradation burdens the clearance function of microglia during aging

    Safaiyan et al. demonstrate that myelin fragments progressively pinch off from aged myelin sheaths and are taken up and cleared by microglia. Age-associated myelin breakdown is substantial and saturates the degra...

    Shima Safaiyan, Nirmal Kannaiyan, Nicolas Snaidero, Simone Brioschi… in Nature Neuroscience (2016)

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    Article

    Cell type– and brain region–resolved mouse brain proteome

    The authors performed a comprehensive proteome analysis of the adult mouse brain, its major regions and CNS cell types at a depth of >13,000 proteins. This new resource represents the largest collection of cel...

    Kirti Sharma, Sebastian Schmitt, Caroline G Bergner, Stefka Tyanova… in Nature Neuroscience (2015)