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Open AccessRadiotherapy statements of the 18th St. Gallen International Breast Cancer Consensus Conference—a German expert perspective
To summarize the radiotherapy-relevant statements of the 18th St. Gallen Breast Cancer Consensus Conference and interpret the findings in light of German guideline recommendations.
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Article
Operative Therapie des Mammakarzinoms: „One size does not fit all“
Die operative Therapie des Mammakarzinoms hat sich in den letzten Jahren erheblich verändert und unterliegt weiterhin einem kontinuierlichen Wandel. Der Beitrag definiert die aktuellen Standards und stellt neu...
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Aktuelle Strategien zur Systemtherapie des frühen Mammakarzinoms von der 18. Internationalen St.-Gallen-Konsensuskonferenz
Seit über 30 Jahren findet regelmäßig die Internationale St.-Gallen(SG)-Konsensuskonferenz zur Behandlung des primären Mammakarzinoms (SGBCC) statt. Bei diesem Konsensus handelt es sich um ein internationales ...
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Article
Open AccessTh2/Th17 cell associated cytokines found in seroma fluids after breast cancer surgery
The development of a seroma after breast cancer surgery is a common postoperative complication seen after simple mastectomy and axillary surgery. We could recently demonstrate that breast cancer patients under...
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Article
Open AccessKLF11 is an independent negative prognostic factor for breast cancer from a cohort study and induces proliferation and inhibits apoptosis in vitro
The therapy concepts that target several members of krüppel like factor (KLF) family have been achieved in breast cancer (BC). However, the role of KLF11 in BC remains unclear. This study explored the prognost...
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Open AccessCurrent trends in diagnostic and therapeutic management of the axilla in breast cancer patients receiving neoadjuvant therapy: results of the German-wide NOGGO MONITOR 24 survey
In the last 2 decades, the optimal management of the axilla in breast cancer patients receiving neoadjuvant chemotherapy (NACT) has been one of the most frequently discussed topics. Little is known about the a...
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Article
Open AccessThe role of E-Cadherin expression in primary site of breast cancer
The tumour’s ability to metastasize is the major cause for fatal outcomes in cancer diseases. In breast cancer, aberrant E-Cadherin expression has been linked to invasiveness and poor prognosis.
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Article
Correction to: Cytoplasmic LXR expression is an independent marker of poor prognosis for patients with early stage primary breast cancer
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Open AccessCytoplasmic LXR expression is an independent marker of poor prognosis for patients with early stage primary breast cancer
The aim of this study was to investigate the expression of liver X receptors α/β (LXR) in primary breast cancer (BC) tissues and to analyze its correlations with clinicopathological parameters including patien...
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Article
Open AccessTP53 germline mutations in the context of families with hereditary breast and ovarian cancer: a clinical challenge
TP53germline (g) mutations, associated with the Li-Fraumeni syndrome (LFS), have rarely been reported in the context of hereditary breast and ovarian cancer (HBOC). The prevalence and cancer risks in this target ...
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Article
Open AccessBreast adipose tissue macrophages (BATMs) have a stronger correlation with breast cancer survival than breast tumor stroma macrophages (BTSMs)
An abundance of tumor-associated macrophages has been shown to be an independent prognostic factor for a poor prognosis of human breast cancer (BC). Adipose tissue accounts for the largest proportion of the br...
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Open AccessCytoplasmic versus nuclear THR alpha expression determines survival of ovarian cancer patients
Thyroid hormone receptors (THR) have manifold functions and are involved in the carcinogenesis of several tumor types. Within this study, we aimed to investigate the expression pattern (nuclear versus cytopla...
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Article
Open AccessExpression of H3K4me3 and H3K9ac in breast cancer
Breast cancer is the leading cause of cancer death in females. Histone modifications have been shown to have an influence on the gene expression. This study focusses on the histone modifications H3K9ac and H3K...
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Article
Open AccessCytoplasmic PPARγ is a marker of poor prognosis in patients with Cox-1 negative primary breast cancers
The aim of this study was to investigate the expression of the nuclear receptor PPARγ, together with that of the cyclooxygenases Cox-1 and Cox-2, in breast cancer (BC) tissues and to correlate the data with se...
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Evaluation of the anti-Thomsen–Friedenreich antibodies Nemod-TF1 and Nemod-TF2 as prognostic markers in breast cancer
The TF (Thomsen–Friedenreich, CD176, Galβ1-3GalNAc) carbohydrate moiety is known as a specific oncofetal carbohydrate epitope present in fetal and neoplastic tissue as well as in stem cells. TF was demonstrate...
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Article
Open AccessThe FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer
Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, whic...
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Article
Tastbefund an der Brust: Auch bei Männern immer abklären!
In Deutschland erkranken jährlich zwischen 600 und 650 Männer an Brustkrebs. Aufgrund des geringen öffentlichen Bewusstseins und fehlender Vorsorgeuntersuchungen wird die Erkrankung aber oft erst in einem fort...
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Open AccessEP3 (prostaglandin E2 receptor 3) expression is a prognostic factor for progression-free and overall survival in sporadic breast cancer
In various cancers, overexpression of cyclooxygenase (COX)-2 and elevated prostaglandin (PG) E2 synthesis have been associated with tumor development and progression. The potential of COX-2 inhibitors in cance...
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Smoking and physical inactivity increase cancer prevalence in BRCA-1 and BRCA-2 mutation carriers: results from a retrospective observational analysis
The aim of this analysis in a pilot study population was to investigate whether we can verify seemingly harmful lifestyle factors such as nicotine and alcohol indulgence, obesity, and physical inactivity, as w...
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Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer
Roger Milne and colleagues conduct a genome-wide association study for estrogen receptor (ER)-negative breast cancer combined with BRCA1 mutation carriers in a large cohort. They identify ten new risk variants an...
