-
Article
Open AccessAssociations between anxiety, sleep, and blood pressure parameters in pregnancy: a prospective pilot cohort study
The potential effect modification of sleep on the relationship between anxiety and elevated blood pressure (BP) in pregnancy is understudied. We evaluated the relationship between anxiety, insomnia, and short ...
-
Article
Open AccessLeveraging electronic health records and knowledge networks for Alzheimer’s disease prediction and sex-specific biological insights
Identification of Alzheimer’s disease (AD) onset risk can facilitate interventions before irreversible disease progression. We demonstrate that electronic health records from the University of California, San ...
-
Article
Reassessing acquired neonatal intestinal diseases using unsupervised machine learning
Acquired neonatal intestinal diseases have an array of overlap** presentations and are often labeled under the dichotomous classification of necrotizing enterocolitis (which is poorly defined) or spontaneous...
-
Article
Open AccessMultimodal machine learning for modeling infant head circumference, mothers’ milk composition, and their shared environment
Links between human milk (HM) and infant development are poorly understood and often focus on individual HM components. Here we apply multi-modal predictive machine learning to study HM and head circumference ...
-
Article
Open AccessCorrection: Digital health application integrating wearable data and behavioral patterns improves metabolic health
-
Article
Open AccessDiscovery of sparse, reliable omic biomarkers with Stabl
Adoption of high-content omic technologies in clinical studies, coupled with computational methods, has yielded an abundance of candidate biomarkers. However, translating such findings into bona fide clinical ...
-
Article
Open AccessDigital health application integrating wearable data and behavioral patterns improves metabolic health
The effectiveness of lifestyle interventions in reducing caloric intake and increasing physical activity for preventing Type 2 Diabetes (T2D) has been previously demonstrated. The use of modern technologies ca...
-
Article
Open AccessQuantitative estimate of cognitive resilience and its medical and genetic associations
We have proposed that cognitive resilience (CR) counteracts brain damage from Alzheimer’s disease (AD) or AD-related dementias such that older individuals who harbor neurodegenerative disease burden sufficient...
-
Article
Open AccessDeep representation learning identifies associations between physical activity and sleep patterns during pregnancy and prematurity
Preterm birth (PTB) is the leading cause of infant mortality globally. Research has focused on develo** predictive models for PTB without prioritizing cost-effective interventions. Physical activity and slee...
-
Article
Open AccessCross-species comparative analysis of single presynapses
Comparing brain structure across species and regions enables key functional insights. Leveraging publicly available data from a novel mass cytometry-based method, synaptometry by time of flight (SynTOF), we ap...
-
Article
Open AccessWhole genome deconvolution unveils Alzheimer’s resilient epigenetic signature
Assay for Transposase Accessible Chromatin by sequencing (ATAC-seq) accurately depicts the chromatin regulatory state and altered mechanisms guiding gene expression in disease. However, bulk sequencing entangl...
-
Article
Open AccessChanges in preterm birth and stillbirth during COVID-19 lockdowns in 26 countries
Preterm birth (PTB) is the leading cause of infant mortality worldwide. Changes in PTB rates, ranging from −90% to +30%, were reported in many countries following early COVID-19 pandemic response measures (‘lo...
-
Article
Open AccessLarge-scale correlation network construction for unraveling the coordination of complex biological systems
Advanced measurement and data storage technologies have enabled high-dimensional profiling of complex biological systems. For this, modern multiomics studies regularly produce datasets with hundreds of thousan...
-
Article
Open AccessAuthor Correction: Early response evaluation by single cell signaling profiling in acute myeloid leukemia
-
Article
Open AccessEarly response evaluation by single cell signaling profiling in acute myeloid leukemia
Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to chemotherapy is poorly understood. In this study, we investigate the initial signaling response to standard induction chemothe...
-
Article
Multiomics, artificial intelligence, and precision medicine in perinatology
Technological advances in omics evaluation, bioinformatics, and artificial intelligence have made us rethink ways to improve patient outcomes. Collective quantification and characterization of biological data ...
-
Article
Omics approaches: interactions at the maternal–fetal interface and origins of child health and disease
Immunoperinatology is an emerging field. Transdisciplinary efforts by physicians, physician‐scientists, basic science researchers, and computational biologists have made substantial advancements by identifying...
-
Article
Open AccessTowards multiomic analysis of oral mucosal pathologies
Oral mucosal pathologies comprise an array of diseases with worldwide prevalence and medical relevance. Affecting a confined space with crucial physiological and social functions, oral pathologies can be mutil...
-
Article
Open AccessHMOX1 Genetic Polymorphisms Display Ancestral Diversity and May Be Linked to Hypertensive Disorders in Pregnancy
Racial disparity exists for hypertensive disorders in pregnancy (HDP), which leads to disparate morbidity and mortality worldwide. The enzyme heme oxygenase-1 (HO-1) is encoded by HMOX1, which has genetic polymor...
-
Article
Open AccessAuthor Correction: Prediction of gestational age using urinary metabolites in term and preterm pregnancies
