-
Article
Open AccessDoing primary care integration: a qualitative study of meso-level collaborative practices
The integration of Primary Care (PC) into broader health systems has been a goal in jurisdictions around the world. Efforts to achieve integration at the meso-level have drawn particular attention, but there a...
-
Article
Open AccessIntroduction and expression of PIK3CAE545K in a papillary thyroid cancer BRAFV600E cell line leads to a dedifferentiated aggressive phenotype
Anaplastic thyroid cancer (ATC) is a rare, aggressive form of undifferentiated thyroid cancer, which exhibits rapid progression and is almost universally fatal. At least a subset of ATC is thought to arise fro...
-
Article
Open AccessTAM family receptors in conjunction with MAPK signalling are involved in acquired resistance to PI3Kα inhibition in head and neck squamous cell carcinoma
Aberrant activation of the phosphatidylinositol 3-kinase (PI3K) pathway is common in many malignancies, including head and neck squamous cell carcinoma (HNSCC). Despite pre-clinical and clinical studies, outco...
-
Chapter
Professionelles Cluster Management als Bestandteil der innovativen Wirtschaftsförderung
Das Cluster Management der Wissenschaftsstadt Darmstadt ist im Amt für Wirtschaft und Stadtentwicklung der Wissenschaftsstadt Darmstadt im Bereich der Wirtschaftsförderung angesiedelt. In den vergangenen siebe...
-
Article
Open AccessGenomic and human papillomavirus profiling of an oral cancer cohort identifies TP53 as a predictor of overall survival
The genomic landscape of head and neck cancer has been reported through The Cancer Genome Atlas project. We attempt to determine if high-risk human papillomavirus (HPV) or frequently mutated genes are correlat...
-
Article
Open Access7th Drug hypersensitivity meeting: part two
Poster walk 11: miscellaneous drug hypersensitivity 2 (P92–P94, P96–P101)
-
Article
Feasibility of Targeting PIK3CA Mutations in Head and Neck Squamous Cell Carcinoma
PIK3CA is the only frequently-mutated, directly druggable oncogene in head and neck squamous cell carcinoma (HNSCC). However, it is unclear if a molecularly-driven intervention trial can ...
-
Article
Open AccessExploiting high-throughput cell line drug screening studies to identify candidate therapeutic agents in head and neck cancer
There is an urgent need for better therapeutics in head and neck squamous cell cancer (HNSCC) to improve survival and decrease treatment morbidity. Recent advances in high-throughput drug screening techniques ...
