9 Result(s)
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Open AccessAuthor Correction: Mutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth
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Open AccessMutant p53 sustains serine-glycine synthesis and essential amino acids intake promoting breast cancer growth
Reprogramming of amino acid metabolism, sustained by oncogenic signaling, is crucial for cancer cell survival under nutrient limitation. Here we discovered that missense mutant p53 oncoproteins stimulate de no...
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Open AccessChanges in the lipidome of water buffalo milk during intramammary infection by non-aureus Staphylococci
This study aimed to determine the lipidome of water buffalo milk with intramammary infection (IMI) by non-aureus staphylococci (NAS), also defined as coagulase-negative staphylococci, using an untargeted lipid...
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Open AccessDNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering
Accumulation of DNA lesions causing transcription stress is associated with natural and accelerated aging and culminates with profound metabolic alterations. Our understanding of the mechanisms governing metab...
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Article
Open AccessMyeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation
Cholesterol homeostasis has a pivotal function in regulating immune cells. Here we show that apolipoprotein E (apoE) deficiency leads to the accumulation of cholesterol in the cell membrane of dendritic cells ...
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Open AccessHDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning
White adipose tissue (WAT) can undergo a phenotypic switch, known as browning, in response to environmental stimuli such as cold. Post-translational modifications of histones have been shown to regulate cellul...
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Open AccessThe ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells
Vγ9Vδ2 T cells are activated by phosphoantigens, such as isopentenyl pyrophosphate (IPP), which is generated in the mevalonate pathway of antigen-presenting cells. IPP is released in the extracellular microenv...
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Open AccessLiver ERα regulates AgRP neuronal activity in the arcuate nucleus of female mice
Recent work revealed the major role played by liver Estrogen Receptor α (ERα) in the regulation of metabolic and reproductive functions. By using mutant mice with liver-specific ablation of Erα, we here demonstra...
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The nuclear receptor LXR is a glucose sensor
The liver has a central role in glucose homeostasis, as it has the distinctive ability to produce and consume glucose1. On feeding, glucose influx triggers gene expression changes in hepatocytes to suppress endog...
