6 Result(s)
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Nicholas F. Lahens
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessDiurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank
Many chronic disease symptomatologies involve desynchronized sleep-wake cycles, indicative of disrupted biorhythms. This can be interrogated using body temperature rhythms, which have circadian as well as slee...
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Article
Open AccessRNA splicing analysis using heterogeneous and large RNA-seq datasets
The ubiquity of RNA-seq has led to many methods that use RNA-seq data to analyze variations in RNA splicing. However, available methods are not well suited for handling heterogeneous and large datasets. Such d...
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Article
Open AccessMOCCASIN: a method for correcting for known and unknown confounders in RNA splicing analysis
The effects of confounding factors on gene expression analysis have been extensively studied following the introduction of high-throughput microarrays and subsequently RNA sequencing. In contrast, there is a l...
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Article
Open AccessA circadian clock regulates efflux by the blood-brain barrier in mice and human cells
The blood-brain barrier (BBB) is critical for neural function. We report here circadian regulation of the BBB in mammals. Efflux of xenobiotics by the BBB oscillates in mice, with highest levels during the act...
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Article
Open AccessComparative evaluation of RNA-Seq library preparation methods for strand-specificity and low input
Library preparation is a key step in sequencing. For RNA sequencing there are advantages to both strand specificity and working with minute starting material, yet until recently there was no kit available enab...
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Article
Open AccessA Pilot Characterization of the Human Chronobiome
Physiological function, disease expression and drug effects vary by time-of-day. Clock disruption in mice results in cardio-metabolic, immunological and neurological dysfunction; circadian misalignment using f...
