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Article
Open AccessCox regression increases power to detect genotype-phenotype associations in genomic studies using the electronic health record
The growth of DNA biobanks linked to data from electronic health records (EHRs) has enabled the discovery of numerous associations between genomic variants and clinical phenotypes. Nonetheless, although clinic...
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Open AccessA Pilot Characterization of the Human Chronobiome
Physiological function, disease expression and drug effects vary by time-of-day. Clock disruption in mice results in cardio-metabolic, immunological and neurological dysfunction; circadian misalignment using f...
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Article
Comprehensive optimization of LC–MS metabolomics methods using design of experiments (COLMeD)
Both reverse-phase and HILIC chemistries are deployed for liquid-chromatography mass spectrometry (LC–MS) metabolomics analyses, however HILIC methods lag behind reverse-phase methods in reproducibility and ve...
