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  1. Article

    Open Access

    RNA splicing analysis using heterogeneous and large RNA-seq datasets

    The ubiquity of RNA-seq has led to many methods that use RNA-seq data to analyze variations in RNA splicing. However, available methods are not well suited for handling heterogeneous and large datasets. Such d...

    Jorge Vaquero-Garcia, Joseph K. Aicher, San Jewell in Nature Communications (2023)

  2. Article

    Open Access

    Enhanced Integrated Gradients: improving interpretability of deep learning models using splicing codes as a case study

    Despite the success and fast adaptation of deep learning models in biomedical domains, their lack of interpretability remains an issue. Here, we introduce Enhanced Integrated Gradients (EIG), a method to ident...

    Anupama Jha, Joseph K. Aicher, Matthew R. Gazzara, Deependra Singh in Genome Biology (2020)