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  1. Article

    Open Access

    Clinical associations with a polygenic predisposition to benign lower white blood cell counts

    Polygenic variation unrelated to disease contributes to interindividual variation in baseline white blood cell (WBC) counts, but its clinical significance is uncharacterized. We investigated the clinical conse...

    Jonathan D. Mosley, John P. Shelley, Alyson L. Dickson… in Nature Communications (2024)

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  2. Article

    Open Access

    An updated, computable MEDication-Indication resource for biomedical research

    The MEDication-Indication (MEDI) knowledgebase has been utilized in research with electronic health records (EHRs) since its publication in 2013. To account for new drugs and terminology updates, we rebuilt ME...

    Neil S. Zheng, V. Eric Kerchberger, Victor A. Borza, H. Nur Eken… in Scientific Reports (2021)

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  3. Article

    Diverse functional autoantibodies in patients with COVID-19

    COVID-19 manifests with a wide spectrum of clinical phenotypes that are characterized by exaggerated and misdirected host immune responses1–6. Although pathological innate immune activation is well-documented in ...

    Eric Y. Wang, Tianyang Mao, Jon Klein, Yile Dai, John D. Huck, Jillian R. Jaycox… in Nature (2021)

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    Article

    Exome-wide association study of plasma lipids in >300,000 individuals

    Exome-wide genetic analysis on >300,000 individuals identifies associations with plasma lipid traits. Loci significantly associated with cholesterol and triglycerides are examined together to determine the eff...

    Dajiang J Liu, Gina M Peloso, Haojie Yu, Adam S Butterworth, **ao Wang… in Nature Genetics (2017)