19 Result(s)

Article

Distinguishing features of long COVID identified through immune profiling

Post-acute infection syndromes may develop after acute viral disease¹. Infection with SARS-CoV-2 can result in the development of a post-acute infection syndrome known as long COVID. Individuals with long COVID f...

Jon Klein, Jamie Wood, Jillian R. Jaycox, Rahul M. Dhodapkar, Peiwen Lu… in Nature (2023)

Article

Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection

Identification of host determinants of coronavirus infection informs mechanisms of viral pathogenesis and can provide new drug targets. Here we demonstrate that mammalian SWItch/Sucrose Non-Fermentable (mSWI/S...

** Wei, A**kya Patil, Clayton K. Collings, Mia Madel Alfajaro… in Nature Genetics (2023)

Article

Plasmodium infection is associated with cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein

Sero-surveillance can monitor and project disease burden and risk. However, SARS-CoV-2 antibody test results can produce false positive results, limiting their efficacy as a sero-surveillance tool. False posit...

Sarah Lapidus, Feimei Liu, Arnau Casanovas-Massana, Yile Dai… in Scientific Reports (2022)

Article

Gut microbiome dysbiosis in antibiotic-treated COVID-19 patients is associated with microbial translocation and bacteremia

Although microbial populations in the gut microbiome are associated with COVID-19 severity, a causal impact on patient health has not been established. Here we provide evidence that gut microbiome dysbiosis is...

Lucie Bernard-Raichon, Mericien Venzon, Jon Klein… in Nature Communications (2022)

Article

Multiscale PHATE identifies multimodal signatures of COVID-19

As the biomedical community produces datasets that are increasingly complex and high dimensional, there is a need for more sophisticated computational tools to extract biological insights. We present Multiscal...

Manik Kuchroo, Jessie Huang, Patrick Wong, Jean-Christophe Grenier… in Nature Biotechnology (2022)

Article

High-resolution epitope map** and characterization of SARS-CoV-2 antibodies in large cohorts of subjects with COVID-19

As Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to spread, characterization of its antibody epitopes, emerging strains, related coronaviruses, and even the human proteome in naturally...

Winston A. Haynes, Kathy Kamath, Joel Bozekowski… in Communications Biology (2021)

Article

Serological assessment of SARS-CoV-2 infection during the first wave of the pandemic in Louisville Kentucky

Serological assays intended for diagnosis, sero-epidemiologic assessment, and measurement of protective antibody titers upon infection or vaccination are essential for managing the SARS-CoV-2 pandemic. Serolog...

Krystal T. Hamorsky, Adrienne M. Bushau-Sprinkle, Kathleen Kitterman… in Scientific Reports (2021)

Article

Reply to: A finding of sex similarities rather than differences in COVID-19 outcomes

Takehiro Takahashi, Mallory K. Ellingson, Patrick Wong, Benjamin Israelow… in Nature (2021)

Article

Author Correction: Delayed production of neutralizing antibodies correlates with fatal COVID-19

Carolina Lucas, Jon Klein, Maria E. Sundaram, Feimei Liu, Patrick Wong… in Nature Medicine (2021)

Article

Delayed production of neutralizing antibodies correlates with fatal COVID-19

Recent studies have provided insights into innate and adaptive immune dynamics in coronavirus disease 2019 (COVID-19). However, the exact features of antibody responses that govern COVID-19 disease outcomes re...

Carolina Lucas, Jon Klein, Maria E. Sundaram, Feimei Liu, Patrick Wong… in Nature Medicine (2021)

Article

Diverse functional autoantibodies in patients with COVID-19

COVID-19 manifests with a wide spectrum of clinical phenotypes that are characterized by exaggerated and misdirected host immune responses^1–6. Although pathological innate immune activation is well-documented in ...

Eric Y. Wang, Tianyang Mao, Jon Klein, Yile Dai, John D. Huck, Jillian R. Jaycox… in Nature (2021)

Article

Sex differences in immune responses that underlie COVID-19 disease outcomes

There is increasing evidence that coronavirus disease 2019 (COVID-19) produces more severe symptoms and higher mortality among men than among women^1–5. However, whether immune responses against severe acute respi...

Takehiro Takahashi, Mallory K. Ellingson, Patrick Wong, Benjamin Israelow… in Nature (2020)

Article

Longitudinal analyses reveal immunological misfiring in severe COVID-19

Recent studies have provided insights into the pathogenesis of coronavirus disease 2019 (COVID-19)^1–4. However, the longitudinal immunological correlates of disease outcome remain unclear. Here we serially analys...

Carolina Lucas, Patrick Wong, Jon Klein, Tiago B. R. Castro, Julio Silva… in Nature (2020)