6 Result(s)
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Article
Open AccessA village in a dish model system for population-scale hiPSC studies
The mechanisms by which DNA alleles contribute to disease risk, drug response, and other human phenotypes are highly context-specific, varying across cell types and different conditions. Human induced pluripot...
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Article
Open AccessElp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype
Intellectual disability (ID) and autism spectrum disorder (ASD) are the most common neurodevelopmental disorders and are characterized by substantial impairment in intellectual and adaptive functioning, with t...
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Article
Open AccessA transcribed enhancer dictates mesendoderm specification in pluripotency
Enhancers and long noncoding RNAs (lncRNAs) are key determinants of lineage specification during development. Here, we evaluate remodeling of the enhancer landscape and modulation of the lncRNA transcriptome d...
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Article
Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts
Regeneration of the heart muscle after myocardial infarction with cardiomyocytes derived from human embryonic stem cells is demonstrated in non-human primates, with the grafts showing evidence of electromechan...
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Article
Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts
A guinea-pig model of cardiac injury is used to show that human embryonic stem-cell-derived cardiomyocyte grafts can electrically integrate into the injured heart, improving mechanical function and reducing sp...
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Article
Reprogramming the injured heart
When the heart is injured, the muscle does not regenerate and scars are produced. This process can be attenuated in the hearts of live mice by forcing scar-forming cells to become muscle cells. See Articles ...
