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Article
Screening Key Sites of Class 2 Integron Integrase that Impact Recombination Efficiency
By capturing and expressing exogenous resistance gene cassettes through site-specific recombination, integrons play important roles in the horizontal transfer of antimicrobial resistant genes among bacteria. T...
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Article
Open AccessDevelopment of potent antibody drug conjugates against ICAM1+ cancer cells in preclinical models of cholangiocarcinoma
As a highly lethal adenocarcinoma of the hepatobiliary system, outcomes for cholangiocarcinoma (CCA) patients remain prominently poor with a 5-year survival of <10% due to the lack of effective treatment modal...
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Article
Comparison of Class 2 Integron Integrase Activities
Integrons play important roles in the dissemination of antimicrobial resistant genes among bacteria. Class 2 integrons usually has an internal stop codon, TAA, in integrase genes (intI2), leading to a truncated i...
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Article
Open AccessEvolutionary significance of amino acid permease transporters in 17 plants from Chlorophyta to Angiospermae
Nitrogen is an indispensable nutrient for plant growth. It is used and transported in the form of amino acids in living organisms. Transporting amino acids to various parts of plants requires relevant transpor...
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Article
Open AccessGenome-wide analysis of the potato Hsp20 gene family: identification, genomic organization and expression profiles in response to heat stress
Heat shock proteins (Hsps) are essential components in plant tolerance mechanism under various abiotic stresses. Hsp20 is the major family of heat shock proteins, but little of Hsp20 family is known in potato (So...
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Article
Open AccessNatriuretic peptide type C induces sperm attraction for fertilization in mouse
Mammalian spermatozoa undergo selective movement along the isthmus of the oviduct to the ampulla during ovulation, which is a prerequisite for fertilization. The factor(s) that involves in selective spermatozo...
