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Article
Open AccessTranscriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma
Glioblastoma (GBM) is a complex disease with extensive molecular and transcriptional heterogeneity. GBM can be subcategorized into four distinct subtypes; tumors that shift towards the mesenchymal phenotype up...
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Article
Open AccessIntegrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities
The prognostic and therapeutic relevance of molecular subtypes for the most aggressive isocitrate dehydrogenase 1/2 (IDH) wild-type glioblastoma (GBM) is currently limited due to high molecular heterogeneity of t...
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Article
Open AccessAllosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer
Abnormal regulation of β-catenin initiates an oncogenic program that serves as a main driver of many cancers. Albeit challenging, β-catenin is an attractive drug target due to its role in maintenance of cancer...
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Article
Open AccessComprehensive pharmacogenomic characterization of gastric cancer
Gastric cancer is among the most lethal human malignancies. Previous studies have identified molecular aberrations that constitute dynamic biological networks and genomic complexities of gastric tumors. Howeve...
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Article
Open AccessPharmacogenomic analysis of patient-derived tumor cells in gynecologic cancers
Gynecologic malignancy is one of the leading causes of mortality in female adults worldwide. Comprehensive genomic analysis has revealed a list of molecular aberrations that are essential to tumorigenesis, pro...
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Article
Open AccessPotent effect of the MDM2 inhibitor AMG232 on suppression of glioblastoma stem cells
Testing new ways to identify untapped opportunities for glioblastoma therapies remains highly significant. Amplification and overexpression of MDM2 gene is frequent in glioblastoma and disrupting the MDM2−p53 ...
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Chapter and Conference Paper
DeepHCS: Bright-Field to Fluorescence Microscopy Image Conversion Using Deep Learning for Label-Free High-Content Screening
In this paper, we propose a novel image processing method, DeepHCS, to transform bright-field microscopy images into synthetic fluorescence images of cell nuclei biomarkers commonly used in high-content drug scre...
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Article
Open AccessRadiation-inducible miR-770-5p sensitizes tumors to radiation through direct targeting of PDZ-binding kinase
Radiotherapy represents the most effective non-surgical modality in cancer treatment. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression, and are involved in many biological processes a...
